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Showing 2 results for pourkhalili

Khalil pourkhalili, Sohrab Hajizadeh, Ali Khoshbaten, Taki Tiraihi,
Volume 12, Issue 2 (Summer 2008)

Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts were isolated immediately (H60 and H180) or 24 hours later (H60/24 and H180/24), and subjected to 30 minutes of regional ischemia followed by 120 minutes of reperfusion. Incidence and severity of ventricular arrhythmias, mechanical function of the heart and coronary flow were assessed during 120 min of reperfusion. LDH and CK release and infarct size were also assessed. Results: Incidence and severity of reperfusion arrhythmias significantly reduced by hyperoxia pretreatment, especially in the early phase of treanment. H180 reduced the incidence of ventricular fibrillation (VF) to 0% vs. 50% of normoxic control, p<0.05). VF duration decreased in H180 group (0 vs. 50±31s in the NC group, p<0.05) and duration of VT decreased in H60 and H180 groups compared to normoxic control group (NC) (1.5±0.7 s and 7.5±2.5 s vs. 17.7±3.3 s respectively, p<0.05). Hyperoxia improves mycardial contractile function and improves coronary flow during reperfusion. Infarct size and enzymes release were also significantly decreased in early and late phase of hyperoxia pretreatment. Conclusions: These results indicate that hyperoxia pretreatment before induction of regional heart ischemia reduces cardiac infarct size and attenuates reperfusion induced arrhythmias in isolated rat heart. Keywords: Hyperoxia, Ischemia-reperfusion injury, Heart protection, Arrhythmias
Zahra Akbari, Zahra Sedaghat, Mansour Esmaili-Dehaj, Esmat Karamean, Narjes Zarei, Abbas Keshavarzi, Khalil pourkhalili,
Volume 18, Issue 3 (Fall 2014)

Introduction: Ischemic preconditioning (IPC) protects skeletal muscles from ischemia-reperfusion injury and improves physical exercise performance. The purpose of the present study was to determine whether application of remote ischemic preconditioning (RIPC) of upper limbs would affect the pulmonary function tests and the maximal oxygen consumption (VO2max). Methods: Twenty healthy trained and untrained subjects were examined under 2 experimental conditions of control and RIPC groups. All individuals attended the laboratory twice, once as the control group and the next time as the RIPC group in a counterbalanced order. These visits were at least 1 week apart and were taken place at the same time of the day. RIPC was induced using a protocol of three cycles of 5 min ischemia/5 min reperfusion in both arms. Pulmonary function tests and oxygen saturation (SPO2) were measured before and after the RIPC protocol. VO2max was estimated by the Queen Step Test. Results: Analysis of data revealed that RIPC increased FEV1, FEF25-75 and MVV tests in the untrained group, while it increased FVC, FEV1, FEF25-75 and MVV tests in the trained group. Preconditioning also increased VO2max and the maximal heart rate in trained subjects. Conclusion: These results show that pre-exercise induction of limb ischemic preconditioning improves pulmonary function tests and VO2max especially in trained subjects. Thus, this technique may be appropriate for the enhancement of exercise performance in athletes during competitions and also for improving the respiratory function in different pulmonary diseases in the near future.

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