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Showing 3 results for Pilevarian

Fatemeh Khakpay, Parvin Rostami, Aliasghar Pilevarian,
Volume 10, Issue 3 (Fall 2006)
Abstract

Introduction: Effective perception of fear signals is crucial for organism survival. When threated, the organism indicates defensive behaviors. Methods: Elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. Increase in two parameters percent of openarm entries (%OAE) and percent of time spent in the open-arm (%OAT) in the elevated plus- maze were considered as the indexes of fear reduction effect. In this study, the effect of testosterone and naloxone on fear behavior of gonadectomized rats (GDX) was investigated. Also, the interaction of testosterone with naloxone was investigated. Results: Subcutaneous (SC) injections of different doses of testosterone (100, 200, 300, 450 μg /rat) increased the %OAE and %OAT in a dose dependent manner. Maximum response was obtained by 450 μg/rat dose of testosterone (P<0.001). SC injections of opioid receptors antagonist, naloxone 1, 2.5, 5, 7.5 mg / kg reduced %OAE and %OAT (P<0.01) . Conclusion: It may be concluded that testosterone decreases fear behavior and naloxone increased fear behavior. Also the results indicate that there is an interaction between testosteone and naloxone (P<0.001).
Narges Kerachian, Hojjatollah Alaee, Mahin Gharavi-Naini, Aliasghar Pilevarian, Ali Moghimi,
Volume 10, Issue 4 (Winter 2007)
Abstract

Introduction: Previous studies have suggested that plants Avena sativa, Hypericum perforatum, Passiflora incarnata and Lavandula officinalis can affect nervous system and reduce neural excitability and pain. The aim of this study was to evaluate the effect of a mixture of these four plant’s alcoholic extract on morphine withdrawal symptoms. Methods: Experiments were performed on four animal groups of Wistar rats weighing 250-300 g (N= 7). For addiction induction, increasing doses of morphine were injected (Intraperitonealy (i.p.)) during nine days. After scientific identification, the plants were dried in room temperature and pulverized. Four plants powder were mixed with same proportion and then extracted using ethylic alcohol 70% by percolation method and then concentrated by rotary, and administrated at the dose of 400 mg/kg in all experimental groups. Morphine withdrawal syndrome symptoms include standing, stretching, jumping, Limbs shaking, blinking, ptosis, were recorded for 30 minutes. Results: Analysis of results showed a significant reduction of withdrawal symptoms in experimental groups (post and co -treated) in comparison with sham group.. Administration of extract cocktail prior to naloxone induced precipitation of withdrawal syndromes, reduced the expression of syndrome signs. Conclusion: It seems that administration of extract cocktail of these four plants inhibits both development and expression of morphine physical dependence symptoms. Considering the effects of different substances of above mentioned plants on excitability and anxiety mechanisms of the brain, the results of this study support the traditional application of these plants.
Ahdiye Shojaei, Mohammad Shabani, Asghar Pilevarian, Shahrnaz Parsania, Moazameh Razavinasab ,
Volume 16, Issue 2 (Summer 2012)
Abstract

Introduction: For some cancer survivors chemotherapy treatment is associated with lasting motor and cognitive impairments, long after treatment cessation. Cisplatin as an anti-neoplastic agent is extremely toxic and can cause severe tissue damage. In the present study, we elucidated alteration in performance of hippocampus- and cerebellum-related behaviors following acute cisplatin treatment in male and female rats. Methods:Male and female wistar rats (120) were divided randomly into eight (two controls [saline] and 6 cisplatin) groups. Cerebellum- and hippocampus-related behavioral dysfunction in cisplatin-treated (5, 10 and 15 mg/kg/week for 1 week) rats were analyzed using hippocampus and cerebellum- dependent function tasks (Morris Water Maze, Shuttle box, Rotarod and Open field). Results:Exposure to cisplatin impaired motor coordination in male and female rats in all doses. In open field test, the rearing frequency, total distance moved and velocity of both males and females were dramatically affected by exposure to cisplatin. In Morris water maze test, male and female rats that were trained one week after cisplatin injection showed significant memory deficits compared to the saline-treated rats. Conclusion:Hippocampal and cerebellum functions of male and female rats were profoundly affected by exposure to cisplatin. No sex-difference was observed in the most measured variables.

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