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Showing 2 results for Nourshahi

Kamal Ranjbar, Maryam Nourshahi, Mahdi Hedayati, Hossin Taheri,
Volume 15, Issue 1 (Spring 2011)
Abstract

Introduction: Exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. The aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (VEGF) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( MMP-2 and MMP-9), as the degrading factors of basement membrane in sedentary men. Methods: Twelve healthy sedentary men (mean age ± SD = 22.37 ± 2.30 years mean BMI ± SD 23.91 ± 2.74) were randomly selected among the volunteers. After determining VO2 max, subjects exercised on ergometer for 1 h at 70% V02 max. Two ml of blood was taken from antecubital vein immediately after exercise and 2 hours postexercise. Serum VEGF, MMP-2 and MMP-9 were measured by ELISA. Results: Serum levels of VEGF and MMP-2 decreased immediately after exercise. Two hours after exercise, the serum VEGF remained at a lower level but serum MMP-2 returned to basal level. No change was detected in the serum levels of MMP-9 immediately and 2 h after exercise. Conclusion: Acute submaximal exercise decreased the main factors involved in the development of capillary network in sedentary men. This might be due to the fact that the submaximal exercise could not provide the two main stimulating factors of angiogenesis, i.e. shear stress and hypoxia. It could also be explained by the fact that the mechanism of development of capillary network following regular exercise training is different from that following an acute exercise.
Maryam Nourshahi, Samane Koneshlou, Reza Gharakhanlou, Mehdi Hedayati, Tohid Hemmatzade,
Volume 17, Issue 2 (Summer 2013)
Abstract

Introduction: Skeletal muscle is a flexible and ever changing tissue and the role of costameric proteins in its response to different stimuli is not well defined. The aim of this study was to investigate the effect of progressive resistance exercise on β1 integrin and vinculin proteins in fast and slow twitch skeletal muscles of male rats. Methods: Twelve male Wistar rats (weight: 298±5.2 gr age: 3 months) were randomly assigned into trained (n=6) and control (n=6) groups after a period of two weeks of inhabitation. In the beginning of the third week, progressiveresistance exercise protocol (to climb up of one meter ladder, 3 sets, 10 repetitions in each set, at 50%, 75%, and 100% of their own body weight) was performed. The control group did not perform any exercise activity. Twelve hours after the last session of acute exercise, rats (control and trained) were sacrificed and their slow-and fast-twitch muscles) Soleus and Flexor hallucis longus) were collected. An ELISA assay was used to determine alterations occurred in the levels of β1 integrin and vinculin proteins. Statistical analyses were made with independent t tests. Results: The results showed that there was no significant change in β1 integrin levels of fast-twitch muscle and vinculin levels of slow-and fast-twitch muscles (p≥0.05). However, a significant change was detected in β1 integrin level in the slow-twitch muscle (p≤0.05). Conclusion: Since that costameric proteins contribute to the maintenance of the structure and stability of muscles and also have a role in the cell signaling, therefore, resistance exercise can be an effective stimulus in improving slowtwitch muscles for stabilization of the muscle structure.

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