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Showing 2 results for Mofid

Hassan Mohammadhosseniakbari, Bahram Rasoulian, Mahmood Mofid, Seid Mohammad Hassan Hashemimadani, Mahvash Jafari, Ali Noroozzadeh, Hossein Eimani, Gholamreza Baqeri, Hamidreza Taghipour, Ali Khoshbaten,
Volume 12, Issue 2 (Summer 2008)
Abstract

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectomized model. For this purpose plasma creatinine (Cr) and urea, creatinine clearance, fractional excretion of sodium and histological injury score (Jablonski score 0-4) were compared among these groups: IR group (40min of renal ischemia – followed by 24h reperfusion), sham group (no IR) and IPC group (3 times of 2min ischemia – 5min reperfusion before 40min of renal ischemia – followed by 24h reperfusion). Results: Necrosis score was significantly lower in IPC than IR group and cases with Jablonski score = 4 were significantly less frequent in IPC group compared to IR group (11.1% vs. 75%). Plasma Cr and urea, creatinine clearance and fractional excretion of sodium were not significantly different between IPC and IR groups. Cases with plasma urea levels higher than 190 mg/dl and also cases with fractional excretion of sodium beyond 2% were significantly less frequent in IPC group compared to IR group. Conclusion: Using three times of "2min ischemia–5min reperfusion" before the injurious ischemic insult can reduce rat renal histological injury and relatively attenuate functional renal injury.
Mohammad Reza Naghii, Mahmood Mofid, Ali Reza Asgari, Mahdi Hedayati, Maryam Sadat Daneshpour,
Volume 15, Issue 3 (Fall 2011)
Abstract

Introduction: Boron possesses widespread properties and is important for human and animal nutrition. Since Boron is rapidly bioavailable, the objective of the present study was to determine whether acute (hourly or daily), and weekly supplementationcould have any significant biological effects on the synthesis of steroids as well as inflammatory biomarkers. Methods: Eight male volunteers participated in experiments on three occasions (day 0, 1 and 7). On the first day (day 0), a blood sample was collected at 8.00 A. M, followed by ingestion of placebo. On the next day (supplementation- day 1), similar procedure was followed by ingestion of 10 mg of boron capsule. On both occasions samples of blood were collected every 2h for the next 6 h. Subjects consumed a capsule of 10 mg boron every day and on day 7, blood collection was carried out again at 8.00 A.M. Independent sample t-tests were used to evaluate the differences. Results: Plasma boron was significantly increasedfollowing hourly (P=0.002) and weekly (P=0.000) consumption of boron. After one week of supplementation, free testosterone levels were significantly increased (P<= 0.02) and estradiol concentrations were significantly decreased (P<= 0.01). Dihydrotestosterone (DHT), cortisol and Vitamin D showed slight non significant, increases. The ratios of free testosterone/testosterone (FT/T) (P<= 0.001), free testosterone/estradiol (FT/E2) (P<= 0.004) and testosterone/estradiol (T/E2) (P<= 0.009) were significantly increased. Also, all 3 inflammatory biomarkers were decreased after supplementation. Conclusion: Although there are previous studies that report a decrease in proinflammatory cytokines induced by boron consumption, to our knowledge, this is the first human study reporting an increase in plasma free testosterone concentrations following consumption of a boron supplement. This indicates a possible protective role against diseases of pathological conditions for this microelement.

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