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Showing 2 results for Khajeh Pour

Seyedeh Parisa Navabi, Ahmad Ali Moazedi, Hooman Eshagh Harooni, Lotfolah Khajeh Pour,
Volume 17, Issue 2 (Summer 2013)
Abstract

Introduction: Dexamethasone is a synthetic glucocorticoid with possible effects on anxiety and depression because it has direct effects on the hypothalamus-pituitary-adrenal (HPA) and interacts with several neurotransmitter systems such as GABA and glutamate. Methods: Levels of anxiety and depression in rats were measured 40 minutes and 24 hours, respectively, after subcutaneous injection of Dexamethasone Sodium-Phosphate (DEX) 0.5, 1, 5, 10, 20, 30 mg/kg (saline 1ml/kg) in the elevated plus maze and forced swimming test. Results: The results of anxiety test showed a significant decrease in the percentage of open arm time and open arm entries in DEX (1 mg/kg) group compared to the saline groups. The percentage of time spent in the open arms significantly increased in DEX (20mg/kg) compared to the saline group. In terms of locomotor activity (total number of open and closed arms), significant decrease was observed in DEX (1 mg/kg) compared to the saline group. Also, a significant difference between DEX 1 and 20 mg/kg groups was observed. Comparative assessment of depression during total immobility time showed significant increase in DEX (1 mg/kg) compared to saline and also a significant decrease was observed in DEX (30 mg/kg) compared to the saline groups. A significant difference in latency to immobility was also detected between DEX 1 and 30 mg/kg groups. Conclusion: Our findings suggest that administration of DEX induced dual effects on anxiety and depression anxiogenic and depressant effects were observed at lower doses, while anxiolytic or antidepressant effects were detected at higher doses.
Marzieh Khorshidi, Mahnaz Kesmati, Lotfollah Khajeh Pour, Hossein Najaf Zadeh Varzi,
Volume 17, Issue 2 (Summer 2013)
Abstract

Introduction: With the increasing development of nanotechnology, nanomaterials are used instead of conventional compounds. One of these nanomaterials that have many applications in the biomedical field, is iron oxide (Fe2O3) nanoparticles and there is not much research on its effects on the physiological features. So in this research, effect of iron oxide nanoparticles on short and long-term passive avoidance memory and levels of serotonin and dopamine in hippocampus was evaluated in comparison to the bulk type. Methods: In this study, 80 male adult Wistar rats (220±30grams) were used and divided into 10 groups, and the study was performed in two parts in order to measure the behavioral changes and neurotransmitters levels. In the first part, animals received intraperitoneal injections of iron oxide nanoparticles and bulk at different doses (0.2, 1, 5 mg/kg( before training. Then, 90 minutes and 24 hours after training their memory was tested by a step–through instrument. In the second part of the study, right and left hippocampi of every group were extracted after receiving the effective dose (5 mg/kg) of iron oxide nanoparticles and bulk, and neurotransmitters levels were measured by an ELISA kit. Results: Iron oxide nanoparticles caused a disruption in passive avoidance memory in a dose-dependent manner, while bulk iron oxide showed a non significant partial effect. Also both type of iron oxide reduced dopamine levels and increased serotonin levels significantly or relatively in both hippocampi. Conclusion: It seems that iron oxide nanoparticles induce a disruption of memory, which is in part related to the alterations of neurotransmitters levels in hypocampus and the other is associated to its physicochemical properties.

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