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Showing 7 results for Hedayati

Mehrdad Habibi, Giti Torkaman, Babak Goosheh, Mehdi Hedayati,
Volume 13, Issue 1 (Spring 2009)

Blood hypercoagulability or thrombogenicity can be one of the main causes of the cardiovascular diseases in young population without traditional pathologic risk factors such as diabetes mellitus, hypertension or hyperlipidemia. The effect of aerobic exercise on coagulation and fibrinolysis has been studied extensively Regarding to the effectivness of resistance exercises to increase functional ability of men, the purpose of this study was to examine the effects of the combined aerobic-resistance and aerobic exercise on the coagulation activity of healthy young men. 30 young healthy sedentary men (20±5 years old) randomly divided in 3 groups: 10 in the combined, 10 in the aerobic and 10 in nontraining matched control groups The training groups subjects were engaged in a program included, ten session, three times per week, with submaximal intensity and 24 min for every session. The combined group had 12 min resistance exercise, followed by a 12 min aerobic exercise on cycle ergometer although aerobic group had only 24 min aerobic exercise on cycle ergometer. The results revealed that PT decreased and PTT increased in training groups. Fibrinogen decreased significantly in both training groups. It was concluded that both submaximal aerobic-resistance and aerobic exercises, decrease coagulation system activity in young healthy sedentary men.
Mansoor Rezaei, Masoumeh Sabetkasaei, Naser Kalantari, Mahdi Hedayati, Alireza Abadi, Nasrin Omidvar,
Volume 14, Issue 4 (Winter 2011)

Introduction: There is no comprehensive study on the effect of Folate on food intake therefore the present study was carried out to determine the effect of Folate supplementation on serum concentrations of Leptin and Grehlin and food intake in male Wistar rats. Methods: The study was carried out for 42 days during which the animals were weighed weekly their food and water intakes were measured every 48 hours. Serum leptin, ghrelin and insulin were measured using ELISA. Repeated Measures and t-test were done to analyze the data. Results: The amount of water intake in the case group was significantly (p<0.05) higher that the control group, food intake was also higher in the group receiving folate as compared to the control although it did not reach the significance level. The Body weight of the rats receiving the supplement were significantly (p<0.001) higher than the control group. The experimental group had higher serum leptin and lower serum ghrelin levels although not significantly. Serum insulin level was significantly higher in the experimental group (p<0.001). A significant correlation was found between Water and food intake (r=0.9, p<0.001), and between body weight and the food intake (r=0.6, p<0.001). There was a significant correlation between serum insulin level with food intake (r=0.6, p< 0.001) and body weight (r=0.36, p=0.05). Conclusion: Daily folate supplementation for a long period increased body growth and food intake in weaning rats. Since serum ghrelin level was also higher, it is possible that increased weight was related to the other body tissues, rather than adipose tissue.
Shoeib Rezaee, Sedighe Kahrizi, Mehdi Hedayati,
Volume 14, Issue 4 (Winter 2011)

Introduction: This research was aimed at examining acute responses of hormones such as growth hormone (GH), total testosterone (TT), free testosterone (FT), free fatty acid (FFA) and cortisol to resistance (R), endurance (E) and endurance-resistance (ER) exercise. Methods: The participants of this study were 10 healthy young men. R protocol included bench press, lateral pull down, leg extension and leg curl. E protocol comprised of 30 minutes pedaling by cycle ergometer at 70% maximum heart rate. In the ER protocol, the participants first went through the E protocol and after an interval of 15 minutes they performed the R protocol. In the control group they did not do any exercise. Blood samples were collected before, immediately after and 15 minutes after exercise. Results: Results indicated that GH and FT were significantly increased after all 3 protocols (P<0.05). TT and FFA were significantly increased after R and E protocols, respectively (P<0.05). Comparison between groups indicated a significant difference between GH and FT. Cortisol was significantly decreased in the E and ER protocols and the control group (P<0.05) but it did not have a significant decrease in the R protocol. Conclusion: The E and ER protocols can increase GH with lower lactate and cortisol production, while the R protocol provides better anabolic environment for development and hypertrophy of muscle fiber because of higher stress, metabolic and hormonal responses. The increase of FFA after the E protocol was probably the cause of reduction of GH and TT secretion in the ER protocol.
Kamal Ranjbar, Maryam Nourshahi, Mahdi Hedayati, Hossin Taheri,
Volume 15, Issue 1 (Spring 2011)

Introduction: Exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. The aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (VEGF) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( MMP-2 and MMP-9), as the degrading factors of basement membrane in sedentary men. Methods: Twelve healthy sedentary men (mean age ± SD = 22.37 ± 2.30 years mean BMI ± SD 23.91 ± 2.74) were randomly selected among the volunteers. After determining VO2 max, subjects exercised on ergometer for 1 h at 70% V02 max. Two ml of blood was taken from antecubital vein immediately after exercise and 2 hours postexercise. Serum VEGF, MMP-2 and MMP-9 were measured by ELISA. Results: Serum levels of VEGF and MMP-2 decreased immediately after exercise. Two hours after exercise, the serum VEGF remained at a lower level but serum MMP-2 returned to basal level. No change was detected in the serum levels of MMP-9 immediately and 2 h after exercise. Conclusion: Acute submaximal exercise decreased the main factors involved in the development of capillary network in sedentary men. This might be due to the fact that the submaximal exercise could not provide the two main stimulating factors of angiogenesis, i.e. shear stress and hypoxia. It could also be explained by the fact that the mechanism of development of capillary network following regular exercise training is different from that following an acute exercise.
Mohammad Reza Naghii, Mahmood Mofid, Ali Reza Asgari, Mahdi Hedayati, Maryam Sadat Daneshpour,
Volume 15, Issue 3 (Fall 2011)

Introduction: Boron possesses widespread properties and is important for human and animal nutrition. Since Boron is rapidly bioavailable, the objective of the present study was to determine whether acute (hourly or daily), and weekly supplementationcould have any significant biological effects on the synthesis of steroids as well as inflammatory biomarkers. Methods: Eight male volunteers participated in experiments on three occasions (day 0, 1 and 7). On the first day (day 0), a blood sample was collected at 8.00 A. M, followed by ingestion of placebo. On the next day (supplementation- day 1), similar procedure was followed by ingestion of 10 mg of boron capsule. On both occasions samples of blood were collected every 2h for the next 6 h. Subjects consumed a capsule of 10 mg boron every day and on day 7, blood collection was carried out again at 8.00 A.M. Independent sample t-tests were used to evaluate the differences. Results: Plasma boron was significantly increasedfollowing hourly (P=0.002) and weekly (P=0.000) consumption of boron. After one week of supplementation, free testosterone levels were significantly increased (P<= 0.02) and estradiol concentrations were significantly decreased (P<= 0.01). Dihydrotestosterone (DHT), cortisol and Vitamin D showed slight non significant, increases. The ratios of free testosterone/testosterone (FT/T) (P<= 0.001), free testosterone/estradiol (FT/E2) (P<= 0.004) and testosterone/estradiol (T/E2) (P<= 0.009) were significantly increased. Also, all 3 inflammatory biomarkers were decreased after supplementation. Conclusion: Although there are previous studies that report a decrease in proinflammatory cytokines induced by boron consumption, to our knowledge, this is the first human study reporting an increase in plasma free testosterone concentrations following consumption of a boron supplement. This indicates a possible protective role against diseases of pathological conditions for this microelement.
Maryam Nourshahi, Samane Koneshlou, Reza Gharakhanlou, Mehdi Hedayati, Tohid Hemmatzade,
Volume 17, Issue 2 (Summer 2013)

Introduction: Skeletal muscle is a flexible and ever changing tissue and the role of costameric proteins in its response to different stimuli is not well defined. The aim of this study was to investigate the effect of progressive resistance exercise on β1 integrin and vinculin proteins in fast and slow twitch skeletal muscles of male rats. Methods: Twelve male Wistar rats (weight: 298±5.2 gr age: 3 months) were randomly assigned into trained (n=6) and control (n=6) groups after a period of two weeks of inhabitation. In the beginning of the third week, progressiveresistance exercise protocol (to climb up of one meter ladder, 3 sets, 10 repetitions in each set, at 50%, 75%, and 100% of their own body weight) was performed. The control group did not perform any exercise activity. Twelve hours after the last session of acute exercise, rats (control and trained) were sacrificed and their slow-and fast-twitch muscles) Soleus and Flexor hallucis longus) were collected. An ELISA assay was used to determine alterations occurred in the levels of β1 integrin and vinculin proteins. Statistical analyses were made with independent t tests. Results: The results showed that there was no significant change in β1 integrin levels of fast-twitch muscle and vinculin levels of slow-and fast-twitch muscles (p≥0.05). However, a significant change was detected in β1 integrin level in the slow-twitch muscle (p≤0.05). Conclusion: Since that costameric proteins contribute to the maintenance of the structure and stability of muscles and also have a role in the cell signaling, therefore, resistance exercise can be an effective stimulus in improving slowtwitch muscles for stabilization of the muscle structure.
Fatemeh Aghaie, Homayoun Khazali, Mehdi Hedayati, Ali Akbarnejad,
Volume 20, Issue 4 (December 2016)

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinological pathologies in women during their reproductive years with ovulatory dysfunction, abdominal obesity, hyperandrogenism and insulin resistance. The aim of the present research was to evaluate the total antioxidant capacity (TAC), total oxidant status (TOS), free testosterone, ovarian morphology and estrous cyclicity in the estradiol valerate (EV)-induced PCOS rat model and the effect of treadmill and running wheel exercises on these parameters. Methods: Fifty female Wistar rats were randomly selected (220 ± 20 g). They had every 2 to 3 consecutive estrous cycles during 12 to 14 days. The first two groups were divided into control (n=10) and polycystic (n=40) that were induced PCOS by EV injection after 60 days. The polycystic groups were divided into three groups (n=10 in each group) PCOS, experiment group with treadmill exercise (running for 28 m/min at 60 min/day) and experiment group with running wheel exercise (running daily for 4 hours) for 8 weeks. Results: The PCOS rats had significantly higher testosterone, TOS and lower TAC than control. Eight weeks of treadmill and running wheel exercise significantly increased serum levels of TAC (just for treadmill exercise) and decreased level of TOS and T (just for treadmill exercise) in EV-induced PCOS rats compared to PCOS group. Ovarian morphology and estrous cycle was almost normalized in the PCOS exercise (treadmill and running wheel) groups. Conclusion: The present study demonstrate EV-induced PCOS in rats is associated with an increased oxidative stress and this increase can be returned to normal levels by exercise.

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