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Showing 4 results for Hajizadeh moghaddam

Masoumeh Sabetkasaei, Amin Ataie, Abbas Haghparast, Akbar Hajizadeh moghaddam, Ramin Ataie, Shiva Nasiraei,
Volume 13, Issue 3 (Fall 2009)

Introduction: Aging is the major risk factor for neurodegenerative diseases and oxidative stress is involved in the pathophysiology of these diseases. Oxidative stress can induce neuronal damages and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. Methods: In this study, we investigated the possible antioxidant and neuroprotective properties of the polyphenolic antioxidant compound, Curcumin against homocysteine (Hcy) neurotoxicity. Curcumin (5, 15, 45 mg/kg) was injected intraperitonealy once daily for a period of 10 days beginning 5 days prior to Hcy (0.2 μmol/μl) intracerebroventricular injection in rats. Biochemical and behavioral studies, including passive avoidance learning and locomotor activity tests were studied 24 h after the last curcumin or its vehicle injection. Also Histopathological studies and cell dencity in different regions of hippocampus was investigated. Results: Hcy could induce lipid peroxidation and increase MDA and SOA levels in rats' brain. Additionally, Hcy impaired memory retention in passive avoidance learning test. However, Curcumin treatment decreased MDA and SOA levels significantly as well as improved learning and memory in rats. Histopathological analysis also indicated that Hcy could decrease hippocampus cell count and Curcumin inhibited this toxic effect. Conclusion: These results suggest that Hcy may induce lipid peroxidation in rats' brain and decrease hippocampus cells. Also polyphenol treatment (Curcumin) has the ability to improve learning and memory deficits by protecting the nervous system against Oxidative stress. Keywords: Homocysteine, Curcumin, Lipid peroxidation, Oxidative Stress
Morteza Gholami, Akbar Hajizadeh moghaddam,
Volume 16, Issue 3 (Fall 2012)

Introduction: Several studies have reported anti-anxiety effects of morphine in adult rats. The present study examined the effect of chronic morphine injections in infancy and before puberty on anxiety-like behavior in immature rats. Methods: Neonate rats (n=35) were randomly chosen and divided into two groups. On postnatal days 8-14, one group received saline and the other one received morphine. On postnatal day 21, each group was divided into subgroups. These subgroups received either morphine or saline according to the type of group on postnatal days 22-28. Finally, on postnatal days 22 and 28, rate of anxiety was studied in a plus maze. Results: On day 24 after birth, morphine increased percentage of open arm time in all groups (P<0.001). This percentage on day 28 was highest for morphine groups compared with the control group (P<0.001). The number of open arm entry on day 24 after birth was significantly increased, for both groups treated with morphine (P<0.05). The greatest difference was observed on day 28 for re-treated rats with fixed dose of morphine compared to the control group (P<0.001). Locomotor activity on days 24 and 28 after birth for both groups treated with morphine was more than the other groups (P <0.05). Conclusion: Chronic morphine administration in the neonatal period caused reduced anxiety-like behavior in immature rats. Also, re-exposure to morphine at a fixed dose had an age related anti-anxiety effect that increased in older rats.
Shahram Shahmohamadi, Akbar Hajizadeh moghaddam, Maryam Khosravi,
Volume 17, Issue 2 (Summer 2013)

Introduction: Oxidative stress is the result of imbalance between free radicals and the antioxidant defense mechanisms of the body. Oxidative stress in brain causes dysfunction of brain activities, destruction of neurons, and disorders like Alzheimer disease. In this experimental study, we examined the protective effect of Salvia officinalis L. against oxidative stress induced by intracerebroventricular injection of streptozotocin in male rats. Methods: In the experimental research, Wistar rats were divided into control, sham, and experimental groups. Experimental groups received 25, 50 and 100 mg/kg body weight of hydroalcoholic extract of Salvia officinalis intraperitoneally. After two weeks, surgical procedure was performed on sham and experimental groups and after one week of recovery, streptozotocin was injected intracerebroventricularly (i.c.v-STZ) at 3 mg/kg. Brain hemispheres were separated after four weeks. Finally, superoxide dismutase (SOD) and catalase (CAT) levels were measured in brain hemispheres. Results: In the group receiving STZ, CAT and SOD levels were significantly decreased compared to the control group (P<0.001), whereas intraperitoneal injection of different doses of Salvia officinalis leaves extract significantly increased SOD and CAT levels compared to STZ group (P<0.001). Conclusion: These data show that antioxidant effects of Salvia officinalis L. could prevent oxidative stress induced by i.c.v.-STZ injection in the brains of male rats.
Mahboobeh Aghagolzadeh, Akbar Hajizadeh moghaddam, Bagher Seyedalipour,
Volume 21, Issue 1 (March 2017)

Introduction: Oxidative stress seems to play a critical role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Antioxidant compounds can deactivate and scavenge free radical. Olive leaves are considered as a useful source of phenolic compounds. Therefore, this study was designed to investigate the effects of methanolic olive leaf extract (OLE) on neurobehavioral activity and antioxidant enzyme activity, malondialdehyde (MDA) and glutathione (GSH) levels in striatum of rats in an experimental model of PD. Methods: The PD was induced in animals by intrastriatal injection of 6-hydroxydopamin unilaterally. Animals were pretreated with the OLE (50, 100 and 150 mg/kg body weight) for 7 weeks, and then behavioral activity (narrow beam and grip testes) and antioxidant parameters were evaluated. Results: In our study behavioral testes showed improvement in motor coordination and balance behavior in rats pretreated with OLE. Furthermore the extract of olive leaf restored the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and decreased MDA and increased GSH levels in the brain of rats. Conclusion: Our results suggest that OLE shows a neuroprotective effect in animal models of Parkinson's disease.

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