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Showing 2 results for Haeri-Rohani

Jafar Vatanparast, Mahyar Janahmadi, Houri Sepehri, Ali Haeri-Rohani, Ali Reza Asgari,
Volume 10, Issue 1 (Spring 2006)

Introduction: Since organophosphorus compounds (OP) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. Although, the main target site of these compounds is acetylcholinesterase (AChE), however it has become increasingly evident that OPs have also other direct effects on cellular processes. In the present study, the effects of low concentrations of paraoxon and its interaction with forskolin, an activator of protein kinase A (PKA), were studied on Ca2+ spike configuration and frequency in neurons of snail Caucasotachea atrolabiata. Methods: Subesophageal ganglia neurons were recorded in current clamp mode in Na+ free Ringer solution that contained voltage dependent potassium channel blockers, 4AP and TEA. Results: Paraoxon (0.3-0.6 μM) decreased the duration of spontaneous Ca2+ spikes. This effect was seen with a suppression of single spike AHPs, leading to an increment in firing rate. Paraoxon induced hyperactivity appeared to be a consequence of decrease in Ca2+ influx during spikes which is the main determinant of AHP duration by activating Ca2+ dependent potassium channels. Forskolin (25 μM), in the absence of a significant change in spike duration, decreased the duration of single spike AHPs and increased the frequency of spikes. After forskolin application, paraoxon decreased the duration of Ca2+ spikes and AHPs, and increased the activity. However, these effects, especially on spike duration, were not as pronounced as in the absence of forskolin. Conclusion: These findings suggest that although forskolin, similar to paraoxon, decreases the AHP and increases the frequency of spikes but it employs mechanism(s) different from paraoxon which also oppose the effects of paraoxon on Ca2+ spikes configuration and frequency.
Parivash Hafez-Amini, Jamal Shams, Ali Shabahng-Saber-Tehrani, Ali Haeri-Rohani, Kazem Parivar, Vahab Babapour, Hedayat Sahraei,
Volume 10, Issue 2 (Summer 2006)

Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.

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