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Showing 4 results for Dehpour

Shahabedin Sadr, Ahmad Reza Dehpour, Namdar Yousofvand, Farokh Shadan, Abbas Norouzi,
Volume 6, Issue 1 (Spring and Summer 2002)
Abstract

In this study, the effect of various doses of ouabain (1, 2, and 5 mg/kg, i.p.) on weight and flow rate of submandibular gland (SMG) and changes in zinc and copper levels in pure saliva and serum of rats was investigated. The time interval between injection of drug and sampling was 30 min. In addition, the effect of a single and toxic dose of ouabain (5 mg/kg, i.p.) in various time intervals (30 min, 1, 2, 3, 7, and 14 days) was also studied. The results showed that in all groups, normalized weight of SMG did not differ significantly. Meanwhile, flow rate decreased 30 min after injection in those animals receiving 2 and 5 mg/kg ouabain and one day after injection in the group receiving 5 mg/kg ouabain. After this time period, all flow rates recovered. In addition, level of zinc increased in serum and saliva in those groups receiving 2 and 5 mg/kg ouabain after 30 min, but it decreased in the group receiving 1 mg/kg of the drug and in recovered groups after 2, 3, and 7 days, serum zinc concentration showed a negligible elevation. Further analysis of data showed that there was no correlation between serum and salivary copper levels. In this respect, only salivary copper level decreased in groups receiving 1, 2, and 5 mg/kg of ouabain and in recovered group after 1 day, whereas copper level only decreased in serum in groups receiving ouabain after 2, 3, and 7 days. Therefore, alterations in zinc level correlate with the inhibitory effects of ouabain on sodium-potassium pump, which may also be the mechanism responsible for the uptake or transport of zinc in this gland. It is noteworthy that alterations in zinc and copper level were opposite of each other in saliva of groups receiving 2 and 5 mg/kg of ouabain and in recovery groups and also in the serum obtained from recovery groups. Taken together, it seems that a period of 14 days is enough for recovery from all of the changes due to the toxic doses of ouabain.
Seyed Shahabedin Sadr, Ahmad Reza Dehpour, Fatemeh Mirershadi,
Volume 7, Issue 2 (Fall and Winter 2003)
Abstract

Considering the clinical significance of opioids, especially their application for the treatment of severe painful conditions including cancer pain and the requirement for the synthesis of more specific drugs with lower side effects, this study was conducted to perform a preliminary investigation on six newly developed opioid drugs. Our aim was to introduce drugs that act selectively on the opioid µ or δ receptors. Since the inhibitory effect of the opioids on the smooth muscle ceIls has already been proved, we have decided to investigate the inhibitory effect of new drugs in this family on the contraction of guinea pig ileum and mouse vas deferens. Each drug was tested for 6 times and the results were evaluated through comparing their IC50 with morphine and with other drugs regarding MVDIC50/GPI IC50 Ratio. The results showed that ail new drugs have inhibitory effects on the muscle twitch, which indicates their agonistic property. Secondly, the new drugs were more selective for µ receptors than δ ones. Third, drug F in guinea pig didn't produce any significant effect in comparison with morphine, but the observed difference for drugs A, B, C, D, and E were significant as compared to morphine. Furthermore, all of them had significant effect on mouse vas deferens in comparison with morphine
Tara Dehpour, Mani Ali Reza, Shahram Ejtemaeimehr, Dehpour Ahmad Reza,
Volume 10, Issue 2 (Summer 2006)
Abstract


Vahid Khori, Ali Mohammad Alizadeh, Hamidreza Moheimani, Delaram Shakiba, Soroosh Soroosh Aminolsharieh Najafi, Shahryar Alizadeh, Taghi Amiriyani, Ardeshir Banikarimi, Mahdi Zahedi, Mohamad Hadi Molseghi, Ahmadreza Dehpour,
Volume 17, Issue 1 (Spring 2013)
Abstract

Introduction: The present study is aimed to evaluate electrophysiological remodeling of atrioventricular (AV) node and ventricular conduction during experimental atrial fibrillation (AF) model in isolated heart of cirrhotic rats. Methods: Cirrhosis-induced electrophysiological remodeling was evaluated in 24 isolated retrogradely perfused rat hearts in 2 groups (control and cirrhotic). Cirrhosis was induced after 6 weeks of common bile duct ligation in rats. Extracellular filed potential was recorded from upper atrium and right ventricle. The conduction time, refractoriness and frequency-dependent properties of AV node were characterized by specific stimulation protocols. Experimental AF was simulated by high-rate atrial pacing with random coupling intervals (range 75–125 ms). Results: Nodal conduction time and ventricular responsiveness were significantly increased in the cirrhotic rats compared to the control (95.8 ± 4.2 ms vs. 78.8 ± 3.3 ms) (P< 0.05). Nodal protective function during AF was potentiated with increased R-R interval, concealed beats, ventricular refractoriness and zone of concealment in the cirrhotic group. Cirrhosis evoked rate–dependent ventricular conduction time shortening with different patterns during arrhythmia. Conclusion: Cirrhosis-induced electrophysiological remodeling was shown by increased AV nodal conduction and shortened ventricular conduction. This electrophysiological remodeling may be considered as a new manifestation of cirrhotic cardiomyopathy in the heart, which can change ventricular rhythm during arrhythmia.

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