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Showing 5 results for Babapour

Parivash Hafez-Amini, Jamal Shams, Ali Shabahng-Saber-Tehrani, Ali Haeri-Rohani, Kazem Parivar, Vahab Babapour, Hedayat Sahraei,
Volume 10, Issue 2 (Summer 2006)

Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.
Hamideh Eftekhari, Ali Haeri Rowhani, Vahab Babapour, Kazem Parivar, Gholamhossein Ranjbar Omrani,
Volume 11, Issue 2 (Summer 2007)

Introduction: Pheromones play a great role in the reproductive and social behavior of animals. The main sources of pheromones are urine and paracrine secretions. Through the neuroendocrine system, prolactin is a safe parameter to measure and compare the effects of pheromones on the sexual, maternal and also lactating behavior. Methods: Female rats were divided into 19 groups (n=8). To measure the plasma prolactin levels of rats, blood samples were collected and tested with prolactin RIA kits. Effects of sexual pheromones in the lactating period (3rd, 6th, 9th and 16th days after delivery), pregnancy priod (7th, 14th and 20th days) and lactating period (6th, 9th and 16th post-delivery days) on plasma prolactin level were surveyed. The effects of sexual pheromones on the plasma level of Prolactin were determined using a special cage without any sensory stimulation interferences, such as visual, auditory and tactile senses. Results: Data showed a significant decline in plasma levels of prolactin following sexual pheromones administration (p<0.05). Significant increase in the prolactin plasma level was observed as the female rats were kept with a castrated male rat (p<0.05). During pregnancy period, prolactin level did not show any significant change in the first week of pregnancy with or without present male rat, but it showed a significant increase during the second and third weeks of pregnancy in the presence of male rat (p<0.01). The presence of male rat during the third, sixth and ninth days after delivery causes a significant increase in prolactin level (p<0.01). The females exposed to alien pups showed a significant decline in prolactin level compared those exposed to their own pups (p<0.05), but both groups showed same level of prolactin on the ninth and sixteenth days of delivery. Conclusion: These findings suggest that male sexual pheromones change plasma levels of prolactin in the pregnancy and lactating period and subsequently affect mating reproductive activities of rats.
Nasrin-Sadat Azami, Morteza Piri, Mehrdad Jahanshahi, Shahrbanoo Oryan, Vahab Babapour, Mohamad Reza Zarrindast,
Volume 14, Issue 1 (Spring 2010)

Introduction: Similarities in the memory impairment between Alzheimer patients and scopolamine treated animals have been reported. In the present study, the possible role of α-adrenergic receptors of the dorsal hippocampus on scopolamine state-dependent memory in adult male Wistar rats was evaluated. Methods: The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-through type inhibitory avoidance task, and tested 24 h after training to measure stepthrough latency. Results: Post-training intra-CA1 administration of scopolamine (0.5 and 2μg/rat) dose-dependently reduced the step-through latency, showing an amnestic response. Amnesia produced by post-training scopolamine (2 μg/rat) was reversed by pre-test administration of the scopolamine (0.5 and 2 μg/rat) that is due to a state-dependent effect. Pre-test intra-CA1 injection of α1-adrenoceptor agonist, phenylephrine (0.25, 0.5 μg/rat) in the dose range that we used, could not affect memory impairment induced by post-training injection of scopolamine (2 μg/rat). However intra-CA1 pretest injection of α2-adrenoceptor agonist, clonidine (0.5 μg/rat) improved post-training scopolamine (2 μg/rat) intra- CA1 injection induced retrieval impairment. Furthermore, pre-test intra-CA1 microinjection of phenylephrine (0.25 and 0.5 μg/rat) or clonidine (0.25 and 0.5 μg/rat) with an ineffective dose of scopolamine (0.25 μg/rat), synergistically improved memory performance impaired by post-training scopolamine (2 μg/rat). Our results also showed that, pre-test injection of α1-receptor antagonist prazosin (1, 2 μg/rat) or α2-receptors antagonist yohimbine (1, 2 μg/rat) before effective dose of scopolamine (2 μg/rat) prevented the improvement of memory by pre-test scopolamine. Conclusion: These results suggest that α1- and α2-adrenergic receptors of the dorsal hippocampal CA1 region may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory.
Sahel Motaghi, Mohammad Niknazar, Mohammad Sayyah, Vahab Babapour, Bijan Vosoughi Vahdat, Mohammad Bagher Shamsollahi,
Volume 16, Issue 1 (Spring 2012)

Introduction: Temporal lobe epilepsy (TLE) is the most common and drug resistant epilepsy in adults. Due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles TLE. This study was aimed at determination of the changes in electroencephalogram (EEG) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. Analysis of these changes might help detection of a pre-seizure state before an oncoming seizure. Methods: Rats were treated by scopolamine (1mg/kg, s.c) to prevent cholinergic effects. After 30 min, pilocarpine (380 mg/kg, i.p) was administered to induce status epilepticus (SE) and 2 hours after SE, diazepam (20 mg/kg, i.p) was injected to suppress the seizures. EEG was recorded in the epileptic rats by superficial electrodes. EEG signal in each rat was decomposed to its sub-bands alpha, beta, gamma, theta and delta by Daubechies wavelet transform. The power (square of amplitude) of sub-band during focal seizures was compared with the same sub-band in pre-ictal stage and the percent of changes in each rat was calculated. Results: SE occurred in 65% of the animals and happened 39.4±5.4 min after injection of pilocarpine. Focal and generalized seizures were developed 3.8±0.4 and 7.0±0.5 days after SE, respectively. Although power of EEG and its sub-bands decreased during focal seizures, the changes were not statistically significant. The greatest decrease in power pertained to beta and gamma sub-bands, while alpha and theta sub-bands underwent the least changes. Conclusion: Based on the protocol used in this study, it seems that the power of EEG sub-bands does not change during focal seizures in pilocarpine model of epilepsy.
Hakimeh Gavzandarounkola, Vahab Babapour, Soroush Sardari, Mohammad Sayyah,
Volume 17, Issue 4 (Winter 2014)

Introduction: Epilepsy is one of the most common neurologic disorders. Pharmacoresistance and adverse effects of current antiepileptic drugs (AEDs) necessitate development of new drugs and strategies for treatment of epilepsy. Omega 3-Polyunsaturated fatty acids (ω3-PUFAs) are safe nutritional supplements that recently considered for treatment of epilepsy. Anticonvulsant effect of docosahexaenoic acid (DHA), the most fatty acid in the brain and neural membrane with important role in modulation of neuronal function, is reported by some researchers. In the present study, the anticonvulsant effect of DHA (before conversion to metabolites) was examined in pentylenetetrazole (PTZ) and maximal electroshock (MES) model of seizures. Methods: Different doses of DHA (0.01, 0.03, 0.075, 0.3, 300 and 1000 μM) were injected into lateral cerebral ventricles (i.c.v.) of adult male NMRI mice. After 15min, clonic seizures were induced by PTZ (60 mg/kg, i.p.) or tonic seizures were induced by maximal electroshock (MES, 50mA, 50Hz, 0.5sec duration). Sodium valproate and phenytoin were injected i.p. as positive control groups for PTZ and MES tests, respectively. Latency to seizure occurrence, number of protected mice and any abnormal behavior in mice were recorded. Results: DHA did not show any protective effect in MES model but increased the latency of seizures and inhibited clonic seizures induced by PTZ with ED50 value of 0.1 μM. Conclusion: Acceptable anticonvulsant activity, good tolerability and low price could suggest DHA as a good candidate for design and development of new anticonvulsant medications.

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