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Showing 6 results for Vitamin E

Jila Behzadi, Mehrdad Roghani,
Volume 3, Issue 2 (11-1999)

  Parkinson's disease (PD) is a human neurodegenerative disorder that is associated with a massive and progressive degeneration of the dopaminergic neurons of the substantia nigra. There is strong evidence that oxidative stress participates in the etiology of PD. Therefore, we designed this study to investigate the neuroprotective activity of vitamin E, a free radical scavenger in the unilateral model of early PD. For this purpose, 6-OHDA lesioned rats were pretreated with d-α-tocopheryl acid succinate (24 I.U./kg, i.m.) and the treatment continued three times a week for a period of one month. Apomorphine- and amphetamine- induced rotations and the number of the WGA-HRP labeled-neurons in the substantia nigra pars compacta were evaluated as indexes of the treatment efficacy. The results of behavioral tests reveal that there is a very significant reduction in drug-induced contraversive (68%) and ipsiversive (74%) rotations in vitamin E-treated lesion group (L+E) compared with the vehicle-treated lesion group (L+V)(p<0.001 ). Histochemical results indicate that the total number of labelled neurons in the substantia nigra pars compacta show a 30% and 65% decrease in L+E (p<0.05) and L+V groups (p<0.01) respectively compared with the sham group. Taken together, these results suggest that vitamin E is moderately effective in the neuroprotective therapy of Parkinson's disease and may, at least prolong the survival of nigral dopaminergic neurons.

Volume 9, Issue 2 (11-2005)

Mohammad Basereh, Ali Heidarianpour,
Volume 18, Issue 1 (3-2014)

Introduction: Oxidative stress is an important factor in the induction of diabetes complications especially peripheral neuropathy and hyperalgesia, and it has been proven that regular aerobic exercise and vitamin E have antioxidant effects. Therefore, this study was designed to examine effects of regular aerobic exercise and vitamin E on thermal pain threshold in streptozocin-induced diabetic rats. Methods: Male Wistar rats (250±10 g) were made diabetic by streptozotocin (60 mg/kg, subcutaneously). One week after diabetes induction, animals were subjected to aerobic exercise and vitamin E treatment for 6 weeks. Aerobic exercise consisted of running on treadmill, and vitamin E (7 g/kg) was added into daily food. Forty eight hours after the end of 3rd and 6th weeks of exercise protocol, we used tail-flick to assess the effects of training and vitamin E on thermal pain threshold. Results: 1) A significant decrease in thermal pain threshold was seen in diabetic rats. 2) Diabetes-induced hyperalgesia decreased significantly by regular aerobic exercise and vitamin E. 3) The effect of simultaneous regular aerobic exercise and vitamin E on thermal pain threshold was significantly more than the effect of each one alone. Conclusion: Regular exercise and vitamin E administration at the time of diabetes induction may be able to restore thermal hyperalgesia. Therefore, they can be used for the treatment and/or management of painful conditions.
Mahboobeh Malakoutikhah, Leila Satarian, Sahar Kiani, Mohammad Javan,
Volume 19, Issue 2 (5-2015)

In addition to its antioxidant effect, Vitamin E or α–tocopherol is suggested to enhance remyelination in the animal model of non-inflammatory demyelination. In this study, the possible proliferative effect of vitamin E on human- induced pluripotent stem cell-derived neural progenitors (hiPS-NPs) and the underlying mechanisms were investigated in vitro. NPs were induced from iPS cells via 3 steps within 18 days and then characterized for NPs markers NESTIN, SOX1 and OTX2. MTT assay was used to compare cell populations. LY294002, U0126 and PP2 were used for selective inhibition of enzymes PI3K, MEK and Src-kinase, respectively. Vitamin E increased hiPS-NPs proliferation after 24 and 48 h exposure. The inhibition of both PI3K/Akt and Src-kinase signaling pathways counteracted the effect of vitamin E of NPs. Our data suggest that vitamin E may enhance NPs proliferation via activating PI3K and Src-kinase and may enhance myelin repair following demyelinating Injuries.
Abbas Alimoradian, Hadi Ansarihadipour, Saeed Changizi-Ashtiyani, Ali Chehrei, Reza Talebi, Sadaf Davudian, Soheila Rostami,
Volume 22, Issue 1 (3-2018)

Introduction: The stress-oxidative is involved in doxorubicin (DOX)-induced cardiotoxicity. Due to the potential and previous reported for antioxidant properties of atorvastatin, omega-3, vitamin E and vitamin C, their efficacy to prevention of DOX-induced cardiotoxicity was investigated in this study. Methods: Fifty-six male rats were divided into 8 groups which received omega-3, atorvastatin, vitamin E, vitamin C, normal saline and dimethyl sulfoxide (DMSO) via gavage for 14 days then a single dose of DOX (20 mg/kg) was injected intraperitoneally except two last groups that received only normal saline or DMSO. The level of oxidative stress parameters like ferric reducing ability of plasma (FRAP) before and after DOX injection and malondialdehyde (MDA) of heart were estimated. Also the histopathologic assessments were done on heart sample at the end of experimental period. Results: The results showed that compared to other agents, omega-3 could emerge as the most protection against DOX. Its pretreatment led to one of the most FRAP changing percent meanwhile less MDA value and cardio pathologic indexes almost close to control groups compared to that of other agents (P<0.01). Conclusion: Omega-3 may have a promising protective effect against DOX-induced cardio toxicity.

Nazanin Entezari Heravi, Reza Mohebbati, Zohreh Naji Ebrahimi, Abolfazl Khajavi Rad, Mohammad Naser Shafei, Mohammad Soukhtanloo, Farimah Beheshti, Sara Hosseinian,
Volume 22, Issue 4 (12-2018)

Introduction: Nephropathy is defined as rational loss of renal function related with glomerulosclerosis and declining glomerular filtration rate. Inflammation and oxidative stress play a critical role in nephropathy. Plantago major has antioxidant effects. The aim of present study is the investigation of the effect of Plantago major hydro-alcoholic extract on the oxidative stress and renal function in kidney of rat. Methods: Rats were divided into five groups: control (Co), doxorubicin (DOX), doxorubicin+vitamin E (DOX+Vit E), 600mg/kg Plantago major (PM)+doxorubicin (PM600+DOX), 1200mg/kg Plantago major (PM)+doxorubicin (PM1200+DOX). DOX (5mg/kg, IV), Vit E and PM extract (600 and 1200mg/kg, PO) were administrated for 35 days. Finally, urine, blood samples and renal tissue were collected to measurement of redox markers, functional parameters and renal index percentage. Results: The renal superoxide dismutase (SOD) activity, total thiol and functional parameters significantly reduced and malondialdehyde (MDA) concentration increased in DOX group in comparison with control group. The renal SOD, catalase activities and total thiol content were significantly increased and MDA level decreased in PM treated groups along with DOX group in comparison with DOX group. The functional parameters significantly enhanced in treated groups with PM in comparison with the DOX group. The extract did not relive enhanced % renal index induced by DOX. Conclusion: Hydro-alcoholic extracts of PM, specially at its high dose led to an improvement in DOX-induced renal function and oxidative stress.

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