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Showing 7 results for Saberi

Mehdi Saberi, Mohamamd Hossein Pourgholami, Masoumeh Jorjani,
Volume 4, Issue 1 (Spring and Summer 2000)

It has been proved that kindling model of amygdala is sensitive to estradiol because the latter accelerates the overall rate of kindling. However the effect of estrogen on the seizure process has not been investigated. In this study fully kindled male rats were treated with different doses (10, 30, and 50 µg/kg, i.p.) of estradiol benzoate (EB) daily and such kindling parameters as seizure stage (SS), after-discharge duration (ADD) and stage 5 duration (S5D) were recorded 15 and 180 min and every 24 h following EB injection for a period of 96 h. While EB at a dose of 10 µg/kg failed to produce a significant effect, but its administration at doses of 30 and 50 µg/kg induced a triphasic effect on seizure parameters. In this regard an initial rapid increment of ADD (after 15 min) was followed by a significant decrease of all parameters after 48 h and then a significant increase in S5D after 96 h was observed. In addition, pretreatment with tamoxifen citrate (TAM) at a dose of 3 mg/kg inhibited the effects of EB (30 µg/kg) for 72 h and pretreatment with TAM at a dose of 10 mg/kg blocked only the inhibitory phase of EB effects after 48 h. Also treatment with the same dose of TAM alone induced a profile similar to EB treatment. These results may suggest that estradiol treatment both increases and decreases kindling parameters in a time- and dose-dependent manner in male rats. These effects probably manifest themselves in genomic and non-genomic forms. Moreover the tamoxifen effects alone could be attributed to its partial agonistic activity on the estrogen receptors.
Valiollah Hajhashemi, Mohsen Minaiyan, Mahdi Saberian-Boroojeni,
Volume 11, Issue 1 (Spring 2007)

Introduction: Urine morphine test, in several countries is the most primarily available qualitative test for detecting opioid abusers. Since the users of illicit drugs attempt to defeat urine tests and there are also plenty of claims that usage of HD (high dose) contraceptive pills can result in false-negative results, we decided to design the present study to investigate the probable in vitro and in vivo interaction of HD contraceptives and urine morphine diagnostic test. Methods: Several high and low concentrations of ethinylestradiol (EE), levonorgestrel (LN), and both of them were made in the blank urine and urine samples obtained from morphine abusers and then were detected by Acon® urine test strips. Also, high and low doses of EE, LN, and both of them were administered orally to separate groups of control, morphine dependent, and morphine treated (20 mg/kg in single dose, s.c.) male Wistar rats (225 ± 25 g). The urine samples were collected during 3-6, 12-15, 21-24 h time intervals in metabolic cages and were examined by Acon® urine tests. Results: Neither contraceptive constituents nor their urine metabolites at different levels were able to negate the results of urine kits. Conclusion: We conclude that there is no interaction between HD contraceptives and urine morphine diagnostic tests both in vitro and in vivo. It is recommended to inform the results of this study to withhold further misusage of contraceptives and their possible adverse effects.
Rafati Rafati, Manijhe Mokhtari-Dizaji, Hajir Saberi, Hosein Chegini,
Volume 12, Issue 1 (Spring 2008)

Instruction: Measurement of brachial artery diameter variation by ultrasound methods has commonly been used to test the endothelial function. It is known that the artery diameter is increased by flow stimulation. Therefore in the present study, the effect of external obstruction, as flow stimulation, on the radial strain of the brachial artery was assessed. Also the biomechanical behavior of the artery due to the changes in obstruction cuff position was evaluated. Methods: Firstly, for evaluating the effect of flow stimulation on healthy men's brachial artery, 200 mmHg pressure and 5 minutes of obstruction was applied. Then, without flow stimulation, it was evaluated by ultrasonic method. In order to evaluate the optimum cuff position with maximum biomechanical variation of the brachial artery, arteries of two regions including the proximal brachial (upper arm) and middle forearm of 10 healthy men were obstructed by 200 mmHg of stress. By acquiring artery diameter variation and estimation of radial strain, multiple frames of the B-mode ultrasonic images were saved on personal computer and maximum artery diameter in the systolic phase, artery diameter in the end of the diastolic phase and the shape of offline were measured. According to relative diameter variations, radial strain percentages were estimated. The effects of external obstruction and the position of this obstruction on the radial strain of the brachial artery were analyzed by t-test. Results: In the first stage, the results of ultrasonic evaluation of the left brachial artery showed that the radial strain induced by stress (200 mmHg) was significantly increased 3.5 times compared to the normal condition without stress. Evaluation of the obstruction's location and its effect on the relative brachial artery diameter showed that with the application of 200 mmHg obstruction in 1/3 of the superior arm and the middle forearm, the radial strain of the artery were 10.44 ± 2.63 % and 4.97 ± 3.61 %, respectively. The statistical analysis of the brachial artery radial strain showed a significant difference between the two obstruction's locations and 33% increase of the obstructed brachial artery's diameter variation in 1/3 of the superior arm. Conclusion: The brachial artery's radial strain is increased by the external obstruction of the artery. This increase seems to be larger in the upper arm region of the artery compared to the middle forearm region.
Mehravar Rafati, Manijhe Mokhtari-Dizaji, Hajir Saberi, Hadi Grailu,
Volume 13, Issue 3 (Fall 2009)

Introduction: This study presents a computerized analyzing method for detection of instantaneous changes of far and near walls of the common carotid artery in sequential ultrasound images by applying the maximum gradient algorithm. Maximum gradient was modified and some characteristics were added from the dynamic programming algorithm for our applications. Methods: The algorithm was evaluated on the common carotid artery of 10 healthy volunteers. Local measurements of vessel intensity, intensity gradient and boundary continuity are extracted for all of the sequential ultrasonic frames throughout three cycles. We extracted the instantaneous changes of far and near arterial walls and hence the lumen diameter. The manual measurements were applied and compared for validation of the automatic method. Peak systolic, end diastolic and mean diameters extracted by the automated method were compared with the same parameters measured by the manual method throughout three cycles. Results: There was no significant difference between automated and manual methods (p>0.05) with paired t-test analysis. In the verification study, correlation between automated and manual methods was excellent (R2 = 0.85, p<0.05) with a negligible bias (0.003 mm) as determined by Bland Altman analysis. Conclusion: It is concluded that computerized analyzing method can automatically detect the instantaneous changes of the arterial walls in sequential B-mode images.
Seyyed Ali Mard, Maryam Maleki, Mohammad Kazem Gharib Naseri, Alihosein Saberi,
Volume 15, Issue 4 (Winter 2012)

Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion in rats. Methods: Forty-nine male Wistar rats (150-200 g) were randomly assigned into 7 groups (7 rats per group). To evaluate the effect of H2S on the basal acid secretion, three groups of animals received an IV bolus of NaHS, a H2S donor, at the doses of 20, 40 or 80 μg/Kg. The effects of IV NaHS 20, 40 or 80 μg/Kg were also investigated on distention-induced gastric acid secretion in other three groups. In order to evaluate the effect of endogenously produced H2S on distention-induced gastric acid secretion, one group of animals received IV propargylglycine (PAG), a cystathionine-γ-lyase inhibitor, 100 mg/kg. Results: NaHS decreased the basal and distention-induced gastric acid secretion in a dose-dependent manner (P<0.01). PAG increased the gastric output in response to distention compared to the control group (P<0.001). Conclusion: Our results showed that both exogenous administration and endogenous production of H2S decrease the gastric acid output. Also, the findings of the present study suggest that endogenously produced H2S has a modulatory effect on stimulated gastric acid output similar to nitric oxide (NO).
Effat Soleimani, Manijhe Mokhtari Dizaji, Hajir Saberi, Shahram Shamshakimi, S. Raiesdana,
Volume 16, Issue 2 (Summer 2012)

Introduction:In this study, a non-invasive method based on consecutive ultrasonic image processing is introduced to assess time rate changes of the carotid artery wall displacement, velocity and acceleration in the longitudinal direction. The application of these parameters to discriminate healthy and atherosclerotic arteries was evaluated. Methods:Longitudinal displacement rate of common carotid artery wall was extracted with temporal resolution of 33 ms using a block-matching algorithm in three groups of subjects. The 3 groups consisted of 16 healthy men (group 1), as well as 16 men with less than 50% (group 2) and 16 subjects with more than 50% atherosclerotic stenosis in carotid artery (group 3). Differentiating the longitudinal displacement equation resulted in time rate changes of instantaneous velocity and acceleration during three cardiac cycles. Maximum and mean values of displacement and maximum and minimum values of velocity and acceleration were compared among the groups. Results:Maximum longitudinal displacement of the arterial wall was 0.438±0.116, 0.653±0.175 and 1.131±0.376 (mm) in groups 1, 2 and 3, respectively. Results of the statistical analysis (ANOVA), with confidence intervals of 95%, confirmed that there are significant differences (p<0.05) among longitudinal movement, velocity and acceleration of three groups of arteries. Conclusion:In the present study, time rate changes of kinematic parameters of the carotid artery wall motion in the longitudinal direction was evaluated, with temporal resolution of 33 ms. Healthy and atherosclerotic arteries were differentiated using these parameters. Our findings may help understanding the biomechanical behavior of the arteries.
Mehrdad Solati, Golamreza Farshidfar, Mohammad Kazam Vakil, Paknoush Saberi, Mohammad Kamalinejad, Nepton Soltani,
Volume 16, Issue 4 (Winter 2013)

Introduction: Recently, the search for appropriate hypoglycemic agents has been focused on plants. Teucrium polium is traditionally used in Iran to manage, control and treat diabetes. We designed this study to elucidate the effect of the administration of oral doses of aqueous and ethanol extract from Teucrium polium on plasma glucose, lipid profiles and liver enzymes in diabetic and non diabetic rats. Methods: In this study, we used 50 rats, which were divided into 5 groups (n=10): two groups served as nondiabetic controls (NDC), while the other groups had diabetes induced with a single injection of streptozotocin (STZ). Teucrium polium-treated chronic diabetic (TE-CD) and Teucrium polium-treated controls (TE-C) received 1g/l of Teucrium polium added to their drinking water for 8 weeks. Results: Administration of Teucrium polium caused Ca/Mg ratio, plasma glucose, glucose tolerance test (IPGTT), high density lipoprotein (HDL), triglyceride, very low density lipoprotein (VLDL) concentrations to return to normal levels, but total cholesterol and low density lipoprotein (LDL) and liver enzyme were increased. Conclusion: Our results support the hypothesis that Teucrium polium could play a role in the management of diabetes, but it has toxic effects on the liver in STZ-induced diabetic rats. It seems that Teucrium polium cannot be used for prevention of type one diabetes.

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