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Showing 2 results for Parsania

Ahdiye Shojaei, Mohammad Shabani, Asghar Pilevarian, Shahrnaz Parsania, Moazameh Razavinasab ,
Volume 16, Issue 2 (Summer 2012)
Abstract

Introduction: For some cancer survivors chemotherapy treatment is associated with lasting motor and cognitive impairments, long after treatment cessation. Cisplatin as an anti-neoplastic agent is extremely toxic and can cause severe tissue damage. In the present study, we elucidated alteration in performance of hippocampus- and cerebellum-related behaviors following acute cisplatin treatment in male and female rats. Methods:Male and female wistar rats (120) were divided randomly into eight (two controls [saline] and 6 cisplatin) groups. Cerebellum- and hippocampus-related behavioral dysfunction in cisplatin-treated (5, 10 and 15 mg/kg/week for 1 week) rats were analyzed using hippocampus and cerebellum- dependent function tasks (Morris Water Maze, Shuttle box, Rotarod and Open field). Results:Exposure to cisplatin impaired motor coordination in male and female rats in all doses. In open field test, the rearing frequency, total distance moved and velocity of both males and females were dramatically affected by exposure to cisplatin. In Morris water maze test, male and female rats that were trained one week after cisplatin injection showed significant memory deficits compared to the saline-treated rats. Conclusion:Hippocampal and cerebellum functions of male and female rats were profoundly affected by exposure to cisplatin. No sex-difference was observed in the most measured variables.
Mohammad Shabani, Taybeh Khezrifard, Mobin Aghapour, Shahrnaz Parsania,
Volume 16, Issue 4 (Winter 2013)
Abstract

Abstract Introduction: Mobile phones create high-frequency electromagnetic fields around them when in use. The close proximity of mobile phones to the user’s head leads to the absorption of part of the electromagnetic waves into the head and the brain. Methods: We have elucidated the alteration in cognitive function of the male and female offspring rats, which were exposed to chronic mobile phone exposure during their gestational period using Shuttle box and Morris Water Maze (~20 days). Results: The results of the passive avoidance and Morris Water Maze assessment of learning and memory performance showed a decrease in learning and memory in rats exposed to mobile phone. Exposure to EMF increased the shock number (Shuttle box test) and distance (Morris Water Maze test) compared to control groups (P<0.05). When the testing was performed 1 and 7 days after the shock experience (28-30 days post- mobile phone exposure), the step-through latency was significantly decreased in male and female mobile phone-exposed rats compared to the control rats (P<0.01). Results from the probe test were measured as mean percentage [%] time spent in correct quadrant showed that mobile phone exposure significantly decreased the percent time spent in the correct quadrant compared to control (p<0.05). Conclusion: Our results suggest that, mobile phone is able to induce a serious disruption in learning and memory and these observed deficits would suggest that we should limit the usage of these instruments during pregnancy.

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