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Showing 5 results for Nematbakhsh

Mehdi Nematbakhsh,
Volume 15, Issue 4 (Winter 2012)

The submitted articles to Iranian congress of physiology and pharmacology could be analyzed for the distribution of research in different fields. Based on field distribution of articles in 20th congress, it seems that a strategic planning for research development in the field of physiology and pharmacology is essential. It is also suggested to revise the congress scientific structure, and to use a common language for research methodology.
Azam Mansoori, Shahrebanoo Oryan, Mehdi Nematbakhsh,
Volume 18, Issue 4 (Winter 2015)

Introduction: Renin angiotensin system has an important role in blood pressure and renal functions. Active angiotensin-converting enzyme 2 converts angiotensin I into angiotensin-(1-7) which is a vasodilator hormone and interacts with nitric oxide changes as well as other angiotensin II receptors. In this study we evaluated the role of Mas receptor antagonist (A779) and renal perfusion pressure (RPP) on serum nitric oxide metabolite (nitrite) concentration when angiotensin II receptors (AT1R & AT2R) were blocked. Methods: After angiotensin II receptors blockage in anesthetized male and female rats, RPP was maintained at two levels 80 & 100 mmHg by occluder around aorta above the renal arteries, and the effects of placebo and A779 on concentration of serum nitrite level were studied. Results: The results showed that when angiotensin II receptors were blocked, the serum level of nitrite in both sexes, was not dependent on angiotensin-(1-7) receptor and did not change statistically, but by increasing renal perfusion pressure and in the presence of angiotensin-(1-7) receptor the serum level of nitrite increased significantly (p<0.05) in male rats but not in female rats. Conclusion: Using angiotensin II receptors blockades and by increase of RPP, the serum level of nitrite is sexrelated. This study showed the importance of Mas receptor in male sex when AT1R & AT2R were blocked.
Mehdi Nematbakhsh, Fariba Azarkish, Ali-Asghar Poorshahnazari,
Volume 19, Issue 1 (March 2015)

Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical procedure to determine BRS using three different doses (0.025, 0.05 and 0.1 mg/kg) of α-adrenergic receptor agonist phenylephrine (PE). Results: Serum levels of blood urea nitrogen and creatinine, kidney weight, and kidney tissue damage score were increased in CP-treated animals. All doses of PE injection caused MAP increase and HR decrease. However, ΔMAP and ΔHR response to 0.1 mg/kg of PE were significantly lower in the CP-treated group (P<0.05). BRS also was increased in a dose-dependent manner by PE in vehicle-treated group, but this was not the case in the CP-treated animals, and significant difference in BRS was detected between the two groups (P<0.05) when 0.05 or 0.1 mg/kg of PE were infused. Conclusion: CP-induced nephrotoxicity attenuates BRS possibly due to peripheral effect on the vascular system.
Jalal Hassanshahi, Maryam Maleki, Mehdi Nematbakhsh,
Volume 21, Issue 4 (December 2017)

Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) reduces renal blood flow and glomerular filtration rate and induces oxidative stress, apoptosis as well as inflammation in renal tissue and contributes to renal fibrosis in UUO model. Also, Ang 1-7 receptor (MasR) and Ang II receptor subtype II (AT2R) may have a protective effect against UUO-induced renal injury. In addition, there is crosstalk among RAS with the main vasodilator factors (prostaglandins E2 and I2, bradykinin, atrial natriuretic factor, nitric oxide and adenosine) and the main vasoconstrictor factors (endothelin and vasopressin) in the ipsilateral kidney with UUO. In this review, the roles of the RAS on renal function and its interactions with the other factors in the kidney with UUO were discussed.

Alireza Samimiat, Mohammad Sedigh Khosravi, Jalal Hassanshahi, Mehdi Nematbakhsh,
Volume 22, Issue 2 (June 2018)

Introduction: Renal ischemia-reperfusion (RIR) may disturb renin-angiotensin system components. In this study, the effects of Mas receptor (A779) and AT2 receptor (PD123319) antagonists were examined in RIR rats. Methods: Total 60 male and female Wistar rats were assigned into 10 groups (n=6 in each group), including sham-operated group, RIR groups treated with the vehicle, A779, PD123319, or A779+PD123319. The rats were subjected to 30 minutes renal ischemia followed by 75 minutes reperfusion and the vehicle/antagonists were started to infuse 15 minutes after beginning of reperfusion for 60 min. Mean arterial pressure (MAP) and renal perfusion pressure responses to antagonists were assessed. Measurements for kidney function parameters also were performed. All the measurements were made at the end of 60 min vehicle/antagonist infusion. Results: MAP has altered significantly during RIR times (P=0.004), but no significant difference was observed between two genders. The RIR itself in injured rats (compared to sham operated rats) decreased urine flow (UF), creatinine clearance (Ccr), filtrate load of sodium (FNa) and sodium excretion rate (ENa) significantly in both genders (P<0.05). The antagonists infusion caused significant decrease in Ccr and FNa in male and female rats subjected to RIR when compared with vehicle (P<0.05), but the UF decreased significantly (P<0.05) only in PD123319 treated groups; however, there was no significant difference in ENa between the RIR groups in both genders. Conclusion: Our findings showed the importance role of Mas receptor and AT2 receptor on renal function after kidney ischemia/reperfusion in RIR rat model.

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