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Showing 27 results for Fathollahi

Farshad Alizadeh Mansouri, Fereshteh Motamedi, Fereshteh Fathollahi, Nafiseh Atapour, Saeed Semnanian,
Volume 1, Issue 1 (Spring and Summer 1997)
Abstract

The effects of chronic morphine administration on the development of long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices using primed-bursts tetanic stimulation. Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation. OPS enhancement was greatest when tested with low to mid-range stimulus intensities (25, 50 and 100 µA). There was also significant decrease in OPS delay. These responses were similar in slices from both control and morphine dependent rats. At all delivered stimulus intensities, the amount of LTP of OPS in slices from dependent rats was larger than that of control slices. However, these differences in LTP of OPS were significant at low stimulus intensities. These findings suggest that chronic morphine administration had induced changes in CA1 neurocircuitry which modulated synaptic plasticity during high frequency stimulation and appeared as augmented LTP and also inhibition of LTP decay.
Farshad Alizadeh Mansouri, Fereshteh Motamedi, Fereshteh Fathollahi, Nafiseh Atapour, Saeed Semnanian,
Volume 1, Issue 1 (Spring and Summer 1997)
Abstract

  The effects of chronic morphine administration on the development of long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices using primed-bursts tetanic stimulation. Significant enhancement of orthodromic population spike (OPS) was found for all stimulus intensities after tetanic stimulation. OPS enhancement was greatest when tested with low to mid-range stimulus intensities (25, 50 and 100 µ A). There was also significant decrease in OPS delay. These responses were similar in slices from both control and morphine dependent rats. At all delivered stimulus intensities, the amount of LTP of OPS in slices from dependent rats was larger than that of control slices. However, these differences in LTP of OPS were significant at low stimulus intensities. These findings suggest that chronic morphine administration had induced changes in CA1 neurocircuitry which modulated synaptic plasticity during high frequency stimulation and appeared as augmented LTP and also inhibition of LTP decay.


Fereshteh Motamedi, Ali Pourmotabbed, Yaghub Fathollahi, Farshad Alizadeh Mansouri, Saeed Semnanian,
Volume 1, Issue 2 (Fall and Winter 1997)
Abstract

  The involvement of NMDA receptors and voltage-dependent calcium channels in augmentation of long-term potentiation (LTP) was investigated at the Schaffer collateral CA1 pyramidal cell synapses in hippocampal slices of morphine dependent rats, using primed-burst tetanic simulation. The amplitude of the population spike and its delay were measured as indices of increase in postsynaptic excitability. D,L-APV and nifedipine were used as an NMDA receptor antagonist and a voltage-dependent calcium channel blocker, respectively. The amount of LTP of the orthodromic population spike (OPS) was higher in slices from dependent rats. Perfusion of slices from control and dependent rats with ACSF containing D,L-APV (25 µ M) and delivering tetanic simulation showed that D,L- APV completely blocked the LTP of OPS in slices from both control and dependent rats, while nifedipine (10 µ M) attenuated the amount of LTP of OPS in dependent slices and had no effect on controls. The results suggest that the enhanced LTP of OPS in the CA1 area of hippocampal slices from morphine-dependent rats is primarily induced by NMDA receptor activity, and the voltage-dependent calcium channels may also be partially involved in this phenomenon.


Mirnajafizadeh, Pourgholami, Fathollahi, Behzadi,
Volume 2, Issue 2 (Fall and Winter 1998)
Abstract

  In this study, the effect of an experimentally increased excitability in hippocampal neurons, via hippocampal kindling, on amygdala kindling rate was investigated in rats. Animals were divided into 4 groups. In all groups, except group 2, tripolar electrodes were implanted in the amygdala and CAI region of the dorsal hippocampus. Group 2 animals were only implanted with tripolar electrodes in the amygdala. In group 1, the rats were kindled one week after surgery, first from the hippocampus, then by amygdala stimulation the next day. In groups 2 and 3, rats were kindled one week after surgery from the amygdala. Group 4 animals had a recovery period of one week plus 32 days, which was the mean of the hippocampal kindling rate in group 1, and then they were kindled from the amygdala. In group 1, the amygdala kindling rate (n number of stimulation trials that must be administered before the stage 5 motor convulsion is triggered) was significantly facilitated and seizure at day n/2 during amygdala kindling was significantly increased. There was also a significant positive correlation between hippocampal and amygdala kindling rates. Results obtained in the present study show that an increase in hippocampal excitability in group 1 could facilitate kindling from the amygdala. Thus it may be suggested that the hippocampus has an important role in the development and propagation of seizures from the amygdala.

  


Mahmood Salami Zavareh, Yaghub Fathollahi, Hossein Esteky, Fereshteh Motamedi, Nafiseh Atapour,
Volume 2, Issue 2 (Fall and Winter 1998)
Abstract


Mahmood Salami, Yaghub Fathollahi, Fereshteh Motamedi, Hossein Esteky,
Volume 3, Issue 1 (Spring and Summer 1999)
Abstract

  The effectiveness of θ pattern primed-bursts (PBs) on development of primed-burst (PB) potentiation was investigated in layer II/III of the adult rat visual cortex in vitro. Experiments were carried out in the visual cortical slices. Population excitatory post-synaptic potentials (pEPSPs) were evoked in layer II/III by stimulation of either white mater or layer IV. To induce long-term potentiation (LTP), eight episodes of PBs were delivered at 0.1 Hz. Regardless of stimulation site, field potential recorded in layer II/III consisted of two components: a short latency and high amplitude response called pEPSP1, and a long latency and low amplitude response called pEPSP2. The incidence of LTP produced by PBs of layer IV was higher than that of the white mater tetanization. In contrast, PBs of both layer IV and white mater reliably induced LTP of pEPSP2 in layer II/III. It is concluded that PBs, as a type of activity pattern, of either white mater or layer IV can gain access to the modifiable synapses that are related to pEPSP2 in layer II/III, but accessibility of the modifiable synapses that are related to pEPSP1 depends on tetanization site. Relevancy of the results to the plasticity gate hypothesis is also discussed.

 


Mohsen Khalili, Saeed Semnanian, Yaghoub Fathollahi,
Volume 4, Issue 1 (Spring and Summer 2000)
Abstract

In this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (PGi) neurons was investigated. The spontaneous activity of PGi neurons was significantly decreased by microinjection of adenosine (10 nM, 0.5 µl) into PGi nucleus of both control and morphine-dependent rats. The decrease in firing rate of PGi neurons of morphine-dependent rats was greater than that of control. There was also significant enhancement of spontaneous activity of PGi neurons 8-15 min after caffeine administration (50 mg/kg i.p.) in both control and morphine-dependent rats. However, the effect of caffeine in morphine-dependent rats was higher than that of control. These data suggest that there is an increase in the sensitivity to chemicals, which interact with adenosine receptors in morphine- dependent rats. Nevertheless, considering a common second messenger system (cAMP) for adenosine (A1) and opioid (µ) receptor, it is proposed that up-regulation and hypersensitivity of A1 adenosine receptors are responsible for these results in morphine-dependent rats.
Mohamamd Reza Palizvan, Yaghoub Fathollahi,
Volume 4, Issue 1 (Spring and Summer 2000)
Abstract

Epilepsy is one of the common disorders in human community. Clinical observations have shown that epileptic patients have often difficulty in learning and memory. Kindling is a laboratory model for studying epilepsy and its complications. This experiment was designed to study the effect of chemical kindling on Schaffer collateral-CA1 pyramidal cell synaptic transmission using pentylenetetrazole in urethane-anesthetized rats. Experiments were carried out on the hippocampal CA1 region from control and kindled rats at two periods post-kindling, i.e. 48-144 h (early phase) and 30-33 day (long-lasting phase). Population spike (PS) was recorded at stratum pyramidale following stimulation of the stratum fibers. The results showed that 48-144 h after kindling, the slope of population excitatory post-synaptic potential (pEPSP), the PS amplitude and spike latency in CA1 region of kindled rats were not significantly different than that of control. In contrast, 30 to 33 days after kindling, the amplitude of PS was significantly greater than that of control (p<0.01). These results suggest that chemical kindling entails long lasting changes in the function of CA1 that appear as enhanced excitability after one month
Mohammad Rostampour, Yaghoub Fathollahi, Saeed Semnanian, Sohrab Hajizadeh, Javad Mirnajafi-Zadeh,
Volume 4, Issue 2 (Fall and Winter 2000)
Abstract

The effect of cysteamine, a somatostatin depletor, on synaptic plasticity induced by tetanic and paired-pulse stimulation was investigated in rat hippocampal CA1. For this purpose, hippocampal slices from saline (1 ml/kg, s.c.) and cysteamine (200 fig/kg, s.c.)-treated and intact rats were used. Population spikes were recorded following Schaffer collateral stimulation. To induce LTP, primed burst tetanic stimulation was used. Paired-pulse stimulation at IPIs of 10, 20, 60, 120, 240, 360, and 480 ms were used and then EPI and PPI of CA1 were calculated. The results showed that the amplitude of population spike (PSA) increased 5, 15, 30, and 60 min after tetanic stimulation and 60 min after primed bursts, PSA increased at all stimulus intensities for all groups. In cysteamine-treated group, the magnitude of LTP was decreased as compared to intact and saline-treated groups. In the latter group, the magnitude of LTP Increased as compared to Intact and cysteamme- treated group. At IPI of 10 ms, mean value of EPI was greater than 1 for intact group and less than 1 for saline- and cysteamine-treated groups. In cysteamine-treated group, the mean value of EPI was significantly less than intact group. At IPIs from 20 to 480 ms, mean value of EPI was greater than or equal to I for all of the groups and no significant difference was observed among them. At IPI of 10 ms, mean value of PPI was greater than I in intact group and less than I in saline- and cysteamine-treated groups. In these groups, mean value of PPI was significantly less than intact group. At IPI of 20 ms, mean value of PPI was greater than I in intact and saline-treated group and less than I in cysteamine-treated group. In the latter group, the mean value of PPI was significantly less than saline-treated and intact groups. At IPIs of 60-680 ms, mean value of PPI was greater than I in all of the groups with no significant difference among them. It is concluded that cysteamine can alter susceptibility of hippocampal CA1 for synaptic plasticity induced by tetanic and paired-pulse paradigms.
Semnanian, Ghaderi Pakdel, Fathollahi, Firoozabadi,
Volume 6, Issue 1 (Spring and Summer 2002)
Abstract

Single unit recording has been used as a well-known technique to study the electrical behavior of neurons. In this respect, the classical methods are rather expensive. In this study a simple and inexpensive method for single unit recording studies has been introduced. Computer sound card was used for data acquisition. Neural responses were saved via simple sound applicable packages and then analyzed for peristimulus time histogram (PSTH) extraction by home-made software. Analog to digital (AID) converter board and sound card simultaneously recorded neuronal activities in two brainstem nuclei (paragigantocellularis lateralis (PGi) and locus ceruleus (LC)). Then, PSTH of data were calculated online for AID captured data and offline for sound card captured data. The results showed that there were no significant differences between PSTH of PGi or LC neurons in two protocols. Therefore, sound cards can be used as well as AID boards for data acquisition in electrophysiological laboratories
Mahmood Salami, Yagoob Fathollahi,
Volume 6, Issue 1 (Spring and Summer 2002)
Abstract

In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-type calcium channels (T-VDCC) decreased potentiation of EPSP1 and partly blocked that of EPSP2. The effect of visual experience on the function of channels was also evaluated. The results showed that T-VDCCs mediate a transient augmentation of EPSP1, while contribute to a stable LTP of EPSP2. Whereas sensory experience influences the occurrence of LTP in field potentials, it seems to be ineffective on the role of calcium channels in synaptic plasticity. It is concluded that the T-VDCCs alone by allowing calcium influx into neurons or by sharing NMDA receptors are involved in the synaptic plasticity.
Yagoob Fathollahi, Batool Rahmati, Saeed Semnanian, Mohammad Reza Vaez Mahdavi, Mahshid Shafizadeh,
Volume 7, Issue 1 (Spring and Summer 2003)
Abstract

The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was used as a measure of LTP induction. The results showed that ketamine (1-100 µM) affected baseline synaptic transmission in a concentration-dependent pattern. Furthennore, ketamine application at a high concentration (50-100 µM) for a period of 20-30 min markedly blocked the induction of LTP, whereas lower concentrations of ketamine (1-10 µM) failed to block LTP. However, ketamine at a concentration of 20 µM affected NMDA-mediated LTP induction in a different pattern. It is concluded that the effect of ketamine on baseline synaptic transmission and LTP induced by a l00 Hz PBs depends on ketamine concentration.
Azam Amini Komijani, Seyed Javad Mirnajafizadeh, Yagoob Fathollahi, Akbar Anayi Godari, Mohammad Mohammadzadeh,
Volume 7, Issue 2 (Fall and Winter 2003)
Abstract

The effects of intraperitoneal injection of N6-cyclohexyladenosine (CHA, a selective adenosine A1 receptor agonist) and 8-cyclopenthyle-I-3-dimethylexanthine (CPT, a selective adenosine A1 receptor antagonist) on entorhinal cortex-kindled seizures were investigated. Fully entorhinal cortex-kindled rats received normal saline (control), CHA (0.06, 0.12 and 0.25 mg/kg) or CPT (0.06 and 0.12 mg/kg) and 15 min later were stimulated at AD threshold. Obtained data showed that intraperitoneal administration of CHA (0.12 and 0.25 mg/kg) reduced entorhinal cortex afterdischarge duration (ADD), duration of stage 5 of the seizure (S5D) and seizure duration (SD) at 15 min post-drug injection. The latency for stage 4 of the seizure (S4L) also increased at these doses. At the dose of 0.06 mg/kg, CHA only reduced S5D. Intraperitoneal injection of CPT increased ADD only at 0.12 mg/kg, but not at 0.06 mg/kg. Pretreatment of animals with CPT (0.06 mg/kg), 5 min before CHA (0.12 mg/kg) blocked the anticonvulsant effects of CHA. Obtained results may indicate that activity of adenosine A1 receptors reduces the severity of entorhinal cortex-kindled seizures.
Leila Satarian, Mohammad Javan, Yagoob Fathollahi,
Volume 10, Issue 1 (Spring 2006)
Abstract

Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of morphine 15 μg/kg, twice a day for 5 days. To study the effect of epinephrine on morphine tolerance, epinephrine (2, 5, 10 or 20 μg/kg, i.t.) was administrated 20 minutes before morphine injection. Analgesia was assessed using tail flick test. Results: In animals that received combined treatments of morphine and epinephrine in doses 2, 5, 10 or 20 μg/ kg for 5 days, at 6th day, morphine produced a more potent analgesia comparing with animals that received saline and morphine during days 1-5. Following tolerance induction during first 5 days, co-administration of epinephrine and morphine during days 6 – 10 reduced the initial tolerance as it induced potent analgesia on day 11th. Conclusion: Our results showed that i.t. administration of epinephrine is able to inhibit and reverse the analgesic tolerance to morphine. It also suggests the possible role of adrenal medulla and epinephrine in mediating the inhibitory effect of stress and HPA activation of the development of analgesic tolerance to morphine.
Parviz Ghorbani Moghadam, Mohammad Mohammad-Zadeh,, Javad Mirnajafi-Zadeh, Yaghub Fathollahi,
Volume 10, Issue 3 (Fall 2006)
Abstract

Introduction: Electrical low-frequency stimulation (LFS) has antiepileptic effect, but the role of different stimulation parameters on this effect has not been determined. In this study the effect of different LFS parameters (intensity, pulse duration and train duration) on piriform-cortex kindled seizures was investigated. Methods: Seizure was produced in animals using kindling model of epilepsy. Then, the effect of LFS on seizure severity was investigated. Results: Different patterns of LFS (1 Hz) applied immediately before kindling stimulation in fully kindled animals, had no significant effect on seizure parameters. In the second experiment, effect of LFS (1 Hz) on inter-seizure interval was investigated. Data showed that daily stimulation of animals for 15 min with LFS for one week after the last kindling stimulation reduced significantly stage 5 seizure duration. Application of the same LFS protocols for three days and two weeks had no significant effect on seizure parameters. In the third experiment, effect of LFS (1 Hz) on kindling rate was investigated. Results showed that when LFS was delivered daily after each kindling stimulation it could decrease afterdischarge duration in various days during kindling and delayed the appearance of seizure stages 1 and 2 significantly. Conclusion: It may be concluded that LFS has antiepileptic effects on kindling acquisition and inter-seizure interval in kindled animals and that the characteristics of LFS protocol (intensity, pulse duration and train duration) have an essential role on these effects.
Ali Rastqar, Mahyar Janahmadi, Yaghub Fathollahi, Mahyar Janahmadi,
Volume 10, Issue 3 (Fall 2006)
Abstract

Introduction: The functional effects of orexin-B on the calcium spikes and excitability of the neuronal soma membrane of garden snail, Helix aspersa were studied. Methods: Conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-B on the configuration and electrophysiological properties of calcium spikes. Results: Application of orexin-B (300 nM) led to a membrane depolarization and thereby the increase in excitability of neurons. It also decreased the duration and the amplitude of calcium spikes. On the other hand, orexin-B had a dual effect on the amplitude of afterhyper polarization (AHP) in a time dependent manner. The maximum reduction of the amplitude of AHP was recorded within 10 min of orexin-B exposure. However a maximum increase in AHP amplitude was observed later (15 min after exposure to orexin-B). Inactivation of G-proteins by pertussis toxin (100 nM) was used to test the involvement of Gi/Go in the orexin-B induced modulation of calcium channels. Pre-incubation of ganglia for 3-6 h with PTX blocked the depolarization effect of orexin-B on the resting membrane potential. Orexin-B on pretreated neuronal cells with PTX did not statistically change the calcium spike parameters, unless the peak amplitude of AHP increased remarkably. Conclusion: In conclusion, these data suggest that orexin-B (300 nM) may affect the membrane excitability and modulates the activity of calcium and calcium activated potassium channels in snail neurons.
Fatemeh Safari, Sohrab Hajizadeh, Yaghoub Fathollahi, Hossein Azizi,
Volume 10, Issue 4 (Winter 2007)
Abstract

Introduction: The relation between morphine and nitric oxide release has been shown. Due to important role of nitric oxide in regulation of skin blood flow, the aim of this study was to investigate the effect of nitric oxide synthase inhibitor (L-NAME) and nitric oxide synthesis precursor (L-arginine) on skin blood flow of intact and morphine-dependent rats. Methods: Skin blood flow of hind paw was measured using Laser Doppler Flowmetry (LDF) technique. Animals became morphine dependent by a well established protocol. Results: Subcutaneous injection of L-arginine (10 or 20 mg/kg) respectively increased skin blood flow by 39% and 64% in intact rats and by 37% and 65% in morphine-dependent rats. There was no significant difference between blood flow in intact and morphine-dependent rats. L-NAME (1 or 5 mg/kg) diminished skin blood flow of intact rats by 35% and 58.7% and skin blood flow of morphine-dependent rats by 29.1% and 60.5%, respectively. There was no significant difference between these two groups. The effect of L-arginine was abolished by pretreatment with L-NAME in morphine-dependent as well as intact groups. Conclusion: Our results suggest that changes in the level of nitric oxide, cause the same skin blood flow alterations in both morphine-dependent and intact rats. More experiments are needed to elucidate the level of nitric oxide release in skin vascular system following dependency.
Mehdi Sadegh, Javad Mirnajafi-Zadeh, Mohammad Javan, Yaghoub Fathollahi, Mohammad Mohammad-Zadeh, Ali Jahanshahi, Zahra Deljo,
Volume 11, Issue 1 (Spring 2007)
Abstract

Introduction: Low-frequency stimulation (LFS) has a delaying effect on kindled seizures acquisition. In the present study we examined the role of galanin receptors in the inhibitory effects of LFS on kindled seizures induced by electrical stimulation of perforant path. Methods: Animals were stimulated daily at the AD threshold intensity with a rapid kindling procedure. LFS was applied immediately after cessation of each kindling stimulation. M35 (0.5 and 1.0 nM per site), a nonselective galanin receptor antagonist, was microinjected daily into the dentate gyrus before the beginning of stimulation protocol and behavioral seizure stages and afterdischarge durations were recorded. Results: LFS application had a suppressive effect on the kindling rate. It significantly increased the number of stimulations needed to reach seizure stages 3, 4 and 5. LFS also decreased the cumulative afterdischarge duration during the days of stimulation. Intra-dentate gyrus microinjection of M35 reduced the inhibitory effect of LFS on kindling rate, significantly. Conclusion: These data indicate that galanin receptors may have a role in mediating part of the inhibitory effects of LFS on perforant path kindled seizures.
Ali Shamsizadeh, Vahid Sheibani, Yaghoub Fathollahi, Mohammad Javan, Javad Mirnajafi-Zadeh, Mohammad Reza Afarinesh,
Volume 11, Issue 2 (Summer 2007)
Abstract

Previous studies have shown that the receptive field properties, spontaneous activity and spatio-temporal interactions of low-threshold mechanical somatosensory cells in the barrel cortex are influenced by C-fibers. In this study, we examined the effect of C-fiber depletion on response properties of barrel cortex neurons following experience dependent plasticity. Methods: In this study, exteracellular single unit recording was performed on 154 barrel cortex neurons in 70 male Wistar rats (38-41days old). For depleting of C-fibers, neonatal rats received an intra-peritoneal injection of capsaicin solution (50 mg/kg) on the first neonatal day. For induction of experience dependent plasticity, all whiskers but D2 on the left muzzle, were plucked from first neonatal day. Neuronal ON and OFF responses were recorded in right barrel cortex following principal whisker (PW) and its caudal adjacent whisker (AW) deflection. Results: Whisker plucking increased PW–evoked ON responses both in capsaicin and vehicle treated rats (all P<0.05). In vehicle treated rats, AW-evoked ON responses were decreased in plucked animals (P< 0.05). Of particular interest, in capsaicin treated rats, AW-evoked ON responses were not decreased in plucked animals. Analyzing OFF responses showed similar result to ON responses. Conclusion: These findings indicate that c-fibers can modulate neuronal response properties following experience dependent plasticity in layer IV of barrel cortex.
Mohammad Mohammad-Zadeh, Javad Mirnajafi-Zadeh, Yaghoub Fathollahi, Mohammad Javan, Parviz Ghorbani,
Volume 11, Issue 2 (Summer 2007)
Abstract

Introduction: Previous studies have been shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulation of perforant path. One group of animals (n=6) received LFS (0.1 ms pulses at 1 Hz, 200 pulse, and 50-150 µA) after termination of each kindling stimulations. In control groups, animals received only kindling stimulations (n=8) or LFS (n=4). Basal field potential recording and paired pulse stimulations were done before kindling stimulations every days. Results: Application of LFS significantly retarded the kindling acquisition and increased the number of stimulations to achieve different seizure stages [F(4,60)=10.9, P<0.0001]. LFS also prevented increment of slope of field excitatory postsynaptic potentials and population spike amplitude during kindling (P<0.001) (There was %88.6±1.7 increment in fEPSP and %94±2.3 increment in PS in kindled group and %3.5±.05 increment in fEPSP and %12.3±0.1 decrease in PS in kindled+LFS group). In addition, LFS prevented the marked increase in early (10-50 ms intervals) and late (300-1000 ms intervals) paired pulse depression induced by kindling significantly (P<0.01). Conclusion: According to obtained results, it may be suggested that LFS of perforant path has a significant antiepileptogenic effect on perforant path kindled seizures through inhibition of synaptic transmission in dentate gyrus. Meanwhile, LFS prevents compensatory increase in the paired pulse depression during kindling acquisition.

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