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Showing 4 results for Etemadi

Vaezi Gholamhasan, Shahrbanoo Oryan, Masoud Fereidoni, Leila Etemadi, Fereshte Manafi,
Volume 11, Issue 2 (Summer 2007)

Based on the extensive application of Peganum harmala (P.h) seeds in the Asian traditional medicine, we tried to investigate its possible anxiety effect. Method: The effect of P.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. The humidity of prepared ethanol extract was 37%. Animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of the extract using Nebulizer. harmaline drug (0.13 gr/ml) was used as positive control drug. Results: Compared with saline treated group, harmaline as the positive control significantly caused fear in rats as it was shown by increased time spent in closed arm of plus-maze (p< 0.05). Also, ethanol extract of P.h was able to show anxiety effect at doses 6, 12 and 18 mg/ml (p <0.05). Conclusion: Our data showed effective anxiety effect of ethanol extract of Peganum harmala. Its effect should be considered in the context of its extensive usage in the men daily life. More studies are required to elucidate its mechanism and site of action.
Vaezi Gholamhassan, Masoud Fereidoni, Leila Etemadi, Maryam Sabzali,
Volume 11, Issue 4 (Winter 2008)

Traditionally, Peganum harmala seeds (P.h) have been extensively used in the Asia region. We have previously reported the increase of fear behavior by systemic administration of P.h extract. Here, we evaluated the effect of central administration of the extract on the fear behavior. Method: Methanolic extract of the plant's seeds (37% humidity) was prepared for the investigation. Elevated plusmaze apparatus was used for evaluating the fear behavior. Adult male rats were categorized in 7 main groups (n=6). 1) Sham control (saline 1 ul/rat, i.c.v) 2) Harmaline treated group (50 ug/rat, i.c.v). 3) Extract treated groups (10, 20, 25, 50, 100 ug/rat i.c.v respectively). Results: All the doses of the P.h Methanolic extract as like as harmaline caused fear behavior (p<0.05). There was no significant difference between the effects of harmaline and the doses of the plant extract. Discusion: Overall, it is possible that the main alkaloid of the P.h (harmaline) is responsible for the increasing of fear behavior. The effect seems to be done trough the central nervous system neurochemical mechanisms.
Masoud Fereidoni, Leila Etemadi,
Volume 12, Issue 2 (Summer 2008)

Introduction: Feverfew (Tanacetum parthenium) (T.p.) is widely used in folk medicine to treat many diseases. We reported the analgesic effect of T.p. flower and leaf previously. Present study is designed to find the mechanism underlying the anti-nociceptive effect of the aqueous extract of T.p. flower. Method: Based on our previous study, the dose 50 mg/kg i.p. of the T.p. aqueous extract had a potent analgesic effect on mice (NMRI) (20 ± 2 g) in formalin test which is used in the present study also. Here, we study the roles of opioidergic, sertoninergic and α - adrenergic systems on the anti-nociceptive effect of the extract. Animals had pretreated with drugs, 15 min before the extract treatments, including opioid antagonist naloxane (5mg/kg, i.p.), sertoninergic antagonist cyproheptadine (4 mg/kg, i.p.) and α-adrenergic antagonist phentolamine (20 mg/kg, i.p.) separately (each group with n≥6). Saline and extract used as controls. Results: In contrast to extract analgesic effect, pretreatment with naloxan increased the pain sensation in the neurogenic phase of formalin test (p<0.001). Pretreatment with cyproheptadine increased the sensation of pain in both early and late phases (p<0.05). Inhibition of α -adrenergic system was not be able to attenuate the anti-nociceptive effect of the extract. Discussion: The involvement of sertoninergic system in anti-nociceptive effect of the T.p. extract is proposed by the results. Also the involvement of opioidergic system has to be mentioned in this effect.
Elham Sheykhsaran, Hossein Bannazadeh Baghi, Mohammad Hossein Soroush Barhaghi, Naser Alizadeh, Mohammad Yousef Memar, Shima Etemadi, Reza Ghotaslou,
Volume 22, Issue 3 (September 2018)

Introduction: Enterobacteriaceae are the heterogeneous group of Gram-negative bacteria, which cause different infections. The incidence of resistance to antibiotics among the Enterobacteriaceae is growing. This study investigated antibiotic resistance features and tetracycline resistance genes distribution in Enterobacteriaceae isolates from Hospitals of Azerbaijan, Iran. Methods: The disc diffusion agar and agar dilution methods were used for assessment of antibiotics susceptibility patterns and minimum inhibitory concentration determination of tetracycline and minocycline. To detect eight tetracycline resistance genes (tetA, tetB, tetC, tetD, tetE, tetG, tetJ, and tetY), the PCR was performed in tetracycline-resistant isolates. Results: The resistance rate to tetracycline, minocycline, doxycycline, and tigecycline by the disc diffusion agar method were 58.8%, 24%, 43.6% and 0.4%, respectively. Fifty-one (20.4%) isolates were multiple drugs resistant. The minimum inhibitory concentration results showed 52% resistance to tetracycline and 22% for minocycline. The percentage of tet genes distribution was tetA (14.4%), tetB (18.4%), tetC (2%) and tetD (4.4%). However, tetE, tetG, tetJ and tetY genes were not detected in the present study. Conclusion: There is a moderate-high resistance rate to tetracycline among Enterobacteriaceae in Azerbaijan. The most effective antibiotic against Enterobacteriaceae was tigecycline followed by fosfomycin, imipenem and meropenem. The tet genes family especially tetA and tetB were prevalent among tetracycline-resistant isolates.

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