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Showing 5 results for Bahrami

Farideh Bahrami, Saeed Semnanian, Ali Khoshbaten,
Volume 11, Issue 2 (Summer 2007)

Assessing the variety and quality of the articles presented in the biennial national congresses of physiology and pharmacology is important to investigators in these fields. Analytic assessment of these presentations are of great use to know the stand points of physiology and pharmacology departments in different universities, and also can be informative for policy makers in higher education nation wide. Methods: In this research we have studied the presentations in the 10th to 17th congresses from different point of views such as general and specified scientific fields, and also the quantity of data production from various departments, universities, and cities. The total number of articles presented in the 10th to 17th congresses was 281, 404, 529, 390, 723, 693, 719, and 687 respectively. Results: This study shows that the city Tehran is a center for productive universities. In addition, the majority of the studies have been systemic and molecular and cellular studies have not still found their expected stand point. Graduate studies seem to be the active generator for research in these fields and need more attention from policy makers. Overall there has been a steady quantitative growth in these presentations. Conclusion: Overall the research activity of Iranian physiologist and pharmacologists could be positively graded but needs great attention to remove the weak points and improve the strong ones.
Mohammad Amin Edalatmanesh, Ahmad Reza Bahrami, Morteza Behnam Rasuli, Ali Moghimi, Maryam Moghadam Matin, Fatemeh Naseri,
Volume 12, Issue 3 (Fall 2008)

Introduction: As an inherited neurodegenerative disease, Huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. Progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. At this stage of knowledge we are, there is no effective therapeutic strategy for diminishing the motor disorders of Huntington's disease. In recent years, cellular transplantation has been an effective therapeutic method for neurodegenerative disease. Material and methods: In this paper, the effects of bone marrow derived mesenchymal stem cells were assessed in animal model of Huntington disease. After causing ipsilateral lesion in striatum with Quinolinic acid, bone marrowe derived mesenchymal stem cells which had been isolated and purified from 4-6 weeks old rats, transplanted into damage striatum. The efficiency of cellular transplantation for improvement of motor disorder was assessed by cylinder test and Apomorphin induced rotation tests, during eight weeks after engraftment. Results: Results show significant improvement (p ≤ 0.0001) in motor disorders and striatal atrophy percent. Conclision: According to results of this assay, cell therapy by means of bone marrow derived adult stem cells promises for treatment of neurodegenerative diseases, especially Huntington's disease.
Mahtab Bahrami, Zahra Ghasemi, Mahyar Janahmadi,
Volume 18, Issue 3 (Fall 2014)

Introduction: Epilepsy is a neurological disorder that affects 1-2% of the world population and about 30% of patients are resistant to antiepileptic drug therapy. Therefore, new treatment alternatives are needed. In the present study, the possible neuroprotective effect of minocycline against epileptiform activity induced by pentylenetetrazole (PTZ) was assessed. Methods: Conventional intracellular recordings were taken from F1 cells of Helix aspersa, under the current clamp condition. Following extracellular application of minocycline alone (300 and 600 μM) or in combination with PTZ (25 mM), alterations in the firing pattern and action potential wave forms were studied and compared to the control group and the group treated with PTZ alone. Results: In the presence of PTZ alone (25mM), neurons displayed paroxysmal depolarization shift (PDS)-like events and produced burst activity. When PTZ was applied following minocycline pretreatment, it did not produce burst activity, and even reduced the firing frequency. In addition, pre-exposure to minocycline prevented almost some of the changes in the AP shape induced by PTZ treatment. Conclusion: The findings indicated that minocycline may be able to exert preventive effects against induction of epileptiform activity and could be possibly considered as a new treatment option for epilepsy.
Sharareh Daryani, Alireza Farzaei, Narges Hosseinmardi, Farideh Bahrami, Mahyar Janahmadi,
Volume 20, Issue 2 (June 2016)

Introduction: Although aging is the most important risk factor for Alzheimer's disease (AD), there is evidence indicating that neuroinflammation may contribute to the development and progression of the disease. Several studies indicated that minocycline may exert neuroprotective effects in rodent models of neurodegenerative diseases. Nevertheless, there are also other studies implying that minocycline has no positive beneficial effects. Thus, the aim of the present study was to assess the preventive effect of minocycline against Aβ-induced changes in intrinsic electrophysiological properties in a rat model of AD. Methods: The present study extended this line of research by examining whether inhibition of microglial activation may alter the intrinsic electrophysiological properties of CA1 pyramidal neurons in a rat model of Aβ neurotoxicity, using whole cell patch clamp. Results: Findings showed that bilateral injection of the Aβ (1-42) into the prefrontal cortex caused membrane hyperpolarization, action potential (AP) narrowing and after hyperpolarization (AHP) amplitude enhancement. It was also resulted in a faster decay time of AP, higher rheobase current, lower firing frequency and smaller post stimulus AHP amplitude. Administration of minocycline (45mg/kg, i.p) not only failed to prevent Aβ-induced alterations in the intrinsic electrophysiological properties, but also enhanced the effects of Aβ on neuronal firing behavior. Conclusion: It can be concluded that minocycline, as a microglial inhibitor, may enhance the disruption of electrophysiological properties of CA1 pyramidal neurons induced by Aβ neurotoxin, including AP parameters and intrinsic neuronal excitability.

Mitra-Sadat Sadat-Shirazi, Ghorbangol Ashabi, Nima Babhadiashar, Mohammadreza Bahrami Hessari, Nasim Vousooghi, Mohammad-Reza Zarrindast,
Volume 22, Issue 1 (Winter 2018)

Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR)  mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants. Results: Data showed there are no differences between two groups in Na+, K+, glucose, urea, creatinine, SGPT, SGOT and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05). Conclusion: Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults.

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