Volume 3, Issue 1 (Spring and Summer 1999)                   Physiol Pharmacol 1999, 3(1): 59-65 | Back to browse issues page

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Effects of visual deprivation on epileptic activity in mature rat visual cortex. Physiol Pharmacol. 1999; 3 (1) :59-65
URL: http://phypha.ir/ppj/article-1-348-en.html
Abstract:   (5568 Views)

  Effects of visual deprivation on the induction of epileptiform activity were studied in layer II/III of mature rat primary visual cortex. Field potentials were evoked by stimulation of layer IV in slices from control and dark-reared (OR) rats. Picrotoxin (PTX)-induced epileptic activity was characterized by spontaneous and evoked epileptic field potentials (EFPs). The results showed that OR slices demonstrate greater susceptibility for induction of spontaneous EFP. PTX-induced changes in the properties of evoked field potentials also showed higher tendency of OR animals to epileptogenesis. In both groups, field potentials are consisted of pEPSP1 (population excitatory post-synaptic potential 1, i.e. first negativity) and pEPSP2 (second negativity). PTX significantly increased the amplitude and duration of pEPSP2, but it had no significant effect on pEPSP1. PTX-induced changes in characteristics of pEPSP2 were significantly higher in OR slices. It is concluded that visual deprivation causes lasting changes in layer II/III of visual cortex that retain in slices and predispose this area for PTX-induced epileptiform activity.

Types of Manuscript: Original Research |