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Castillo-Hernandez M D C, Guevara-Balcazar G, Rubio-Gayosso I, Coral R. Changes in vascular reactivity of the coronary artery and thoracic aorta in mice null in the delta sarcoglycan gene. Physiol Pharmacol. 2017;
URL: http://phypha.ir/ppj/article-1-1298-en.html

Abstract:   (144 Views)

Mutations in the delta sarcoglycan gene cause limb-girdle muscular dystrophy type 2F (LGMD2F) with structural and functional alterations in cardiac, smooth and skeletal muscle. The aim of the present study was to improve  information about changes in vascular reactivity of the thoracic aorta and the coronary artery in the perfused heart of the d-SG-null mutant mouse model. Female knockout and wild-type mice (5 months old). Curves doses response to phenylephrine, angiotensin II, acetylcholine were performed. The results shows an increment in the contractile response to angiotensin II in the aorta and the isolated heart from the KO mice, and it seems due to a major participation of prostanoids. On the other hand the relaxant effect of acetylcholine is less in the KO than in the WT, however this seems due to the participation of prostanoids instead of nitric oxide.  
 

     
Types of Manuscript: Original Research | Subject: Cardivascular system