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moghimian M, abtahi H, shokoohi M, amiri M, soltani M. Effect of Syzygium aromaticum (clove) extract on seminiferous tubules and oxidative stress after testicular torsion in adult rats. Physiol Pharmacol. 2017;
URL: http://phypha.ir/ppj/article-1-1257-en.html

Abstract:   (208 Views)
Introduction: The aim was to investigate the protective effect of the extract of Syzygium aromaticum on damaged tissues and the oxidative stress after testicular torsion.
Methods: Rats were randomly divided into a control group subjected to a sham procedure and three treatment groups comprising testicular torsion followed by detorsion(TD), testicular torsion detorsion followed by the treatment with an extract of Syzygium aromaticum(TDSA), and treatment done by extract of Syzygium aromaticum alone(SA). Testicular torsion was induced by 720 degrees of counterclockwise rotation of the left testis for 4 h. After the duration of the induction of the torsion, detorsion was done. The animals were given daily oral administrations of just Syzygium aromaticum (4 mg/kg) for seven days. The measurement of the oxidative stress and testosterone levels, as well as assessments of histomorphometry were conducted seven days after detorsion.
Results: The Johnsen score, along with the thickness of the epithelium and diameter of the seminiferous tubules, significantly increased in the testicular torsion group after receiving treatment with the extract of Syzygium aromaticum(TDSA) as compared to TD group. The levels of testosterone and GPX also increased significantly in the testicular torsion group after receiving treatment with the extract of Syzygium aromaticum(TDSA) compared to TD group. The MDA levels decreased in the testicular torsion group after receiving treatment with the extract of Syzygium aromaticum (TDSA) compared to TD group.
Conclusions: The findings of the current study suggested that Syzygium aromaticum might have provided a protective effect against testicular torsion detorsion injury
     
Types of Manuscript: Original Research | Subject: Others