Volume 10, Issue 2 (Summer 2006)                   Physiol Pharmacol 2006, 10(2): 135-142 | Back to browse issues page

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Hafez-Amini P, Shams J, Shabahng-Saber-Tehrani A, Haeri-Rohani A, Parivar K, Babapour V et al . Olanzapine antagonizes the acquisition and expression of morphine-induced conditioned place preference in male and female mice. Physiol Pharmacol. 2006; 10 (2) :135-142
URL: http://phypha.ir/ppj/article-1-251-en.html
Abstract:   (13323 Views)
Introduction: Several investigations have indicated that dopamine D receptors could influence morphine 2 eward. The influence of olanzapine (a D dopamine receptor antagonist) on the morphine-induced conditioned 2 lace preference (CPP) in male and female mice was investigated in the present study. Methods: The effects of olanzapine on the acquisition and expression of morphine CPP in male and female -MRI mice (W: 20-25 g) were investigated in the present study. Resultd: Subcutaneous (s.c.) injection of morphine (1-10 mg/kg, three drug sessions) induced place preference oth in male and female mice. Intraperitoneal (i.p.) administration of olanzapine (0.5-5 mg/kg) induced place version (CPA) in female mice but not in male mice. Administration of olanzapine (1, 2.5, 5 mg/kg, i.p.) reduced oth the acquisition and expression of morphine-induced CPP in male and female mice. However, olanzapine (5 g/kg, i.p.) caused more than 80% mortality in female but not male mice. The effects of olanzapine were reversed y L-arginine (20 mg/kg, i.p.) pre-administration. Conlusion: We conclude that olanzapine reduced morphine effects via different mechanism/s.
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Types of Manuscript: Original Research | Subject: Pain and addiction