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Abstract:   (315 Views)

Introduction: Nephropathy is defined as rational loss of renal function related with glomerulosclerosis, declining glomerular filtration rate. Inflammation and oxidative stress play a critical role in nephropathy. Plantago major has antioxidant effects. The aim of present study is the investigation of the effect of hydro-alcoholic extract of Plantago major on the oxidative stress and renal function in kidney of rat.

Methods: Rats were divided into five groups: Control (Co), Doxorubicin (DOX), Doxorubicin+Vitamin E (DOX+Vit E), Plantago major (PM) 600mg/kg +Doxorubicin (PM600+DOX), Plantago major (PM) 1200mg/kg +Doxorubicin (PM1200+DOX). DOX (5mg/kg, i.v), Vit E and PM extract (600 and 1200mg/kg, p.o) were administrated for 35 days. Finally, urine and blood samples and renal tissue were collected to measurement of redox markers, functional parameters and renal index percentage.

Results: The renal content of superoxide dismutase (SOD) activity and total thiol and functional parameters significantly reduced and Malondialdehyde (MDA) concentration increased in DOX group in comparison with Co group. The renal content of SOD activity and total thiol were significantly increased and MDA level decreased in PM treated groups along with DOX group in comparison with DOX group. The functional parameters significantly enhanced in treated groups in comparison with control day in the same groups. The extract did not relive enhanced %renal index induced by DOX.

Conclusion: hydro-alcoholic extracts of PM, specially its high dose led to an improvement in DOX-induced renal function and oxidative stress.

     
Types of Manuscript: Original Research | Subject: Kidney