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Abstract:   (35 Views)
Introduction: An important role of DA signaling in energy homeostasis has been shown in previous studies. Nevertheless, it has not identified a specific role for midbrain or hypothalamic dopamine systems in energy homeostasis. In this regard, the role of ventromedial hypothalamic dopamine D2 receptors (VMH D2Rs) on homeostasis system remains largely unknown.
Methods: Here, we investigated effects of intra-VMH administration of the D2 receptor agonist (Quinpirole) and antagonist (Sulpiride) on leptin and glucose levels in fasted rats.
Results: Results showed that VMH D2R stimulation with Quinpirole increased leptin level, while Sulpiride suppressed it. The VMH D2 activation or blockade also decreased or increased plasma glucose, respectively. A negative correlation was also observed between glucose and leptin levels in drug-treated rats.
Conclusion: These data suggest that altered VMH D2-mediated neurotransmission might contribute to an alteration in the metabolic phenotype of individual. 
 
     
Types of Manuscript: Original Research | Subject: Nervous system (others)