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Abstract:   (452 Views)
Introduction: Learning and memory requires a BDNF-dependent phase in the hippocampus. It has been reported that chronic pain decreases hippocampal BDNF levels. We have also previously reported that noxious stimulation of the rat tooth pulp impairs learning and memory. Therefore, we decided to find the changes in the hippocampal BDNF expression which are associate in tooth pain and learning and memory impairment.
It has been reported that inflammatory dental pain induces learning and memory impairment. It has been also demonstrated that specific growth factors including brain-derived neurotrophic factor (BDNF) have an essential role in cognition, particularly in learning and memory processes.  Furthermore, there is a positive correlation between hippocampal BDNF protein levels and learning performance and memory. Therefore, the current study was designed to investigate the effects of dental pulp pain on the levels of BDNF mRNA and protein in the hippocampus of male rats.

Dental pulp nociception was induced by intradental injection of capsaicin (100 µg) in male Wistar rats. BDNF expression levels were determined by semi-quantitative RT-PCR and western blotting.

The data indicated that capsaicin elicited pain behaviors and impaired learning and memory in Morris water maze test. The Protein and mRNA levels of BDNF were significantly (p<0.05) decreased in capsaicin-treated rats as compared with control animals. Furthermore, iboprofen (120 mg/kg, i.p.) treatment caused a significant (p<0.05) up-regulation of the BDNF protein and mRNA in the hippocampus of capsaicin-injected animals.

Conclusion:These findings suggest that inflammatory dental pain induces hippocampal function impairments by decreasing in BDNF expression.
Types of Manuscript: Original Research | Subject: Nervous system (others)