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Abstract:   (135 Views)
Diabetes Mellitus (DM) linked Alzheimer’s Disease (AD) is known to be one of major challenges to health care system in these days. AD is divided into sporadic AD and familial AD and known to be the most common cause of dementia. Sporadic form of AD results from multiple etiologic factors including metabolic, environmental and genetic factors. Both type 1 and type 2 DM is strongly related to cognitive impairment and known to be a major risk factor in the development of probable Alzheimer’s disease. Nitrosamines present in processed food plays a major role in the development of DM related sporadic form of AD. This review mainly deals with scientific data related to sporadic AD particularly related to DM and the various mechanisms involved in the development of neuronal degeneration associated with chronic hyperglycaemia, biomarkers in the diagnosis and management of AD, DM and prediabetic state related memory impairments.