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Nematbakhsh M, Samimiat A, Khosravi M S, Hassanshahi J. The role of AT2 and Mas receptors blockers on kidney function and hemodynamic markers in male and female rats subjected to renal ischemia-reperfusion. Physiol Pharmacol. 2018;
URL: http://phypha.ir/ppj/article-1-1331-en.html
Abstract:   (196 Views)
Introductions: Renal ischemia-reperfusion (RIR) is recognized as being major cause of acute renal failure that alters the expression of the renin-angiotensin system (RAS) components in a gender dependent manner. In this study, the role of Mas receptor (MasR) antagonist (A779) and AT2 receptor (AT2R) antagonist (PD123319) was examined on renal injury in RIR rats.
Methods: 60 male and female Wistar rats randomly were assigned into 10 groups, including sham operated, RIR received vehicle, A779, PD123319, or A779+PD123319. Rats were subjected to 30 minutes renal ischemia followed by 75 minutes reperfusion. The antagonists were started to infuse 15 minutes after reperfusion. Mean arterial pressure (MAP) and renal perfusion pressure’s (RPP) responses to antagonists were assessed. Measurements for kidney function parameters were performed in serum and urine.
Results: The results showed that MAP has altered significantly during renal ischemia-reperfusion times (p=0.004), but no significant difference was observed between two genders. Moreover, urine flow (UF), creatinine clearance (Ccr), and tubular sodium (TNa) load (TNa load) altered significantly in RIR rats compare with sham operated group (p<0.01). Contrary to the significant decrease of Ccr and TNa load in RIR male, female rats treated with A779 or PD123319 or A77+ PD123319 don’t show significant variation rather than RIR rats treated with vehicle.  However, there was no significant difference in UNa load indicator in all RIR groups with each other.
Conclusion: Our findings would seem to show renal functional responses to MasR and AT2R antagonists are gender dependent in RIR rat model.
Types of Manuscript: Original Research | Subject: Kidney